TY - JOUR
T1 - Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C
AU - Christensen, Peer Brehm
AU - Krarup, Henrik Bygum
AU - Laursen, Alex Lund
AU - Madsen, Poul Henning
AU - Pedersen, Court
AU - Schlichting, Poul
AU - Orholm, Marianne
AU - Ring-Larsen, Helmer
AU - Bukh, Jens Otto Drachmann
AU - Krogsgaard, Kim
PY - 2012/6/7
Y1 - 2012/6/7
N2 - Abstract Objective. The aim of this study was to examine the early viral kinetics as predictor for sustained virological response (SVR) during hepatitis C treatment. Materials and methods. We included patients with biopsy-proven chronic hepatitis C and ALT above the upper limit of normal, who received a standard treatment of pegylated interferon alfa-2a and ribavirin. The HCV-RNA concentration (limit of detection 20 IU/mL) was determined at days 0, 1, 2, 3, 4, 7, 14, 21 and monthly thereafter. Results. Among 46 patients who completed the trial, 30 (65%) had SVR. Low baseline viral load, IL28B genotype CC and absence of cirrhosis were statistically associated with SVR. In multivariate analysis only absence of cirrhosis and HCV-RNA negativity at day 14 were independent predictors for SVR. Eight patients who became HCV-RNA negative on day 14 as well as 13 of 14 patients (93%) with HCV-RNA levels of
AB - Abstract Objective. The aim of this study was to examine the early viral kinetics as predictor for sustained virological response (SVR) during hepatitis C treatment. Materials and methods. We included patients with biopsy-proven chronic hepatitis C and ALT above the upper limit of normal, who received a standard treatment of pegylated interferon alfa-2a and ribavirin. The HCV-RNA concentration (limit of detection 20 IU/mL) was determined at days 0, 1, 2, 3, 4, 7, 14, 21 and monthly thereafter. Results. Among 46 patients who completed the trial, 30 (65%) had SVR. Low baseline viral load, IL28B genotype CC and absence of cirrhosis were statistically associated with SVR. In multivariate analysis only absence of cirrhosis and HCV-RNA negativity at day 14 were independent predictors for SVR. Eight patients who became HCV-RNA negative on day 14 as well as 13 of 14 patients (93%) with HCV-RNA levels of
U2 - 10.3109/00365521.2012.694905
DO - 10.3109/00365521.2012.694905
M3 - Journal article
SN - 0036-5521
VL - 8-9
SP - 1115
EP - 1119
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
ER -