Neurological sequelae remain frequent after bacterial meningitis in children

Morten B Svendsen*, Inge Ring Kofoed, Henrik Nielsen, Henrik Carl Schønheyder, Jacob Bodilsen

*Kontaktforfatter

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

16 Citationer (Scopus)
195 Downloads (Pure)

Abstract

AIM: To examine the incidence, clinical presentation and risk factors for neurological sequelae following childhood community-acquired bacterial meningitis (CABM).

METHODS: We included all children aged 1 month to 15 years old with CABM in North Denmark Region, 1998-2016. Using medical records, we registered baseline demographics, signs and symptoms at admission, laboratory investigations, and outcome assessed by the Glasgow Outcome Scale (GOS). A GOS score of 1-4 was considered an unfavourable outcome. We used modified Poisson regression to examine predefined risk factors for neurological sequelae among survivors.

RESULTS: We identified 88 cases of CABM in 86 patients (45 female) with a median age of 1.4 years (interquartile range 0.7-4.6). Neisseria meningitidis was the most common pathogen (48/88). Neurological sequelae occurred in 23 (27%) as hearing deficits in 13 (15%), cognitive impairment in 10 (12%) and motor or sensory nerve deficits in 8 (9%). Unfavourable outcome was observed in 16 (18%) patients and three (3%) patients died. Abnormalities on cranial imaging remained the only independent risk factor for developing neurological sequelae in adjusted analysis.

CONCLUSION: Neurological sequelae following CABM in children remain frequent and abnormal cranial imaging may be an independent risk factor.

OriginalsprogEngelsk
TidsskriftActa Paediatrica
Vol/bind109
Udgave nummer2
Sider (fra-til)361-367
Antal sider7
ISSN0803-5253
DOI
StatusUdgivet - feb. 2020

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