TY - JOUR
T1 - No effect of hydroxyapatite particles in phagocytosable sizes on implant fixation
T2 - an experimental study in dogs
AU - Rahbek, O
AU - Kold, S
AU - Bendix, K
AU - Overgaard, S
AU - Soballe, K
PY - 2005/5/1
Y1 - 2005/5/1
N2 - The influence of wear debris on bone healing around orthopedic implants is debated. Hydroxyapatite (HA) particles and polyethylene (PE) particles have been shown to have a negative effect on osteoblast cultures in vitro. The present study investigated the in vivo effects of HA and PE particles on the mechanical fixation and gap healing around experimental HA implants. Nonloaded implants (n = 30) were inserted bilaterally into the proximal tibia of 15 dogs with a 2-mm gap to the bone. The peri-implant gap was either (1) empty (n = 6) or filled with (2) hyaluronic acid (n = 8), (3) hyaluronic acid and HA particles (n = 8), or (4) hyaluronic acid and PE particles (n = 8). After 4 weeks, the animals were killed. The implant interface was evaluated by pushout testing until failure and by histomorphometry. Both HA and PE particles were found to be phagocytosed by macrophage-like cells in the interfacial tissue. HA particles were also integrated in newly formed bone. We found no negative effect of the particulate material on mechanical fixation of the implants or on bone formation around the implants.
AB - The influence of wear debris on bone healing around orthopedic implants is debated. Hydroxyapatite (HA) particles and polyethylene (PE) particles have been shown to have a negative effect on osteoblast cultures in vitro. The present study investigated the in vivo effects of HA and PE particles on the mechanical fixation and gap healing around experimental HA implants. Nonloaded implants (n = 30) were inserted bilaterally into the proximal tibia of 15 dogs with a 2-mm gap to the bone. The peri-implant gap was either (1) empty (n = 6) or filled with (2) hyaluronic acid (n = 8), (3) hyaluronic acid and HA particles (n = 8), or (4) hyaluronic acid and PE particles (n = 8). After 4 weeks, the animals were killed. The implant interface was evaluated by pushout testing until failure and by histomorphometry. Both HA and PE particles were found to be phagocytosed by macrophage-like cells in the interfacial tissue. HA particles were also integrated in newly formed bone. We found no negative effect of the particulate material on mechanical fixation of the implants or on bone formation around the implants.
KW - Analysis of Variance
KW - Animals
KW - Biocompatible Materials/pharmacology
KW - Bone Regeneration/drug effects
KW - Dogs
KW - Durapatite/pharmacology
KW - Hyaluronic Acid/metabolism
KW - Microscopy, Electron, Scanning
KW - Phagocytosis/drug effects
KW - Polyethylene/metabolism
KW - Prostheses and Implants
U2 - 10.1002/jbm.a.30245
DO - 10.1002/jbm.a.30245
M3 - Journal article
C2 - 15754330
SN - 1549-3296
VL - 73
SP - 150
EP - 157
JO - Journal of Biomedical Materials Research. Part A
JF - Journal of Biomedical Materials Research. Part A
IS - 2
ER -