Resumé

Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women with MM are scarce. This observational study aimed to elucidate the asbestos exposure patterns among women with MM. Methods All histological and cytological specimens from women diagnosed with MM between 1974–2015 at the Institute of Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational and habitation information were obtained from Danish registries and medical journals based on record linkage via the unique person ID. The number of MM cases in each parish in the region of North Jutland was determined and the incidence density in parishes was used to calculate the spatial relative risk (RR) of MM among women. Results Diagnosis of MM was confirmed in 91 women. Exposure types were classified as occupational (9%), domestic (10%), environmental (22%), combination of domestic and environmental (34%) and unknown (25%). Twenty continuous parishes formed a MM “hotspot” around the asbestos-consuming industries in the city of Aalborg. Of these, the maximum RR was found in a parish housing an asbestos factory [RR 10.5, 95% confidence interval (CI) 5.5–19.4, environmental exposure in particular RR 2.9, 95% CI 0.7–9.1]. Conclusion Non-occupational asbestos exposure is the main cause of MM and may account for up to 66% of MM cases among women in North Jutland, Denmark.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Work, Environment & Health
Vol/bind45
Udgave nummer1
Sider (fra-til)82-89
Antal sider8
ISSN0355-3140
DOI
StatusUdgivet - jan. 2019

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Asbestos
asbestos
Denmark
cause
parish
confidence interval
asbestos industry
confidence
Pathology
pathology
Industrial plants
Malignant Mesothelioma
exposure
woman
factory
Confidence Intervals
incidence
Environmental Exposure
housing
Inhalation

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title = "Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North Jutland, Denmark",
abstract = "Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women with MM are scarce. This observational study aimed to elucidate the asbestos exposure patterns among women with MM. Methods All histological and cytological specimens from women diagnosed with MM between 1974–2015 at the Institute of Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational and habitation information were obtained from Danish registries and medical journals based on record linkage via the unique person ID. The number of MM cases in each parish in the region of North Jutland was determined and the incidence density in parishes was used to calculate the spatial relative risk (RR) of MM among women. Results Diagnosis of MM was confirmed in 91 women. Exposure types were classified as occupational (9{\%}), domestic (10{\%}), environmental (22{\%}), combination of domestic and environmental (34{\%}) and unknown (25{\%}). Twenty continuous parishes formed a MM “hotspot” around the asbestos-consuming industries in the city of Aalborg. Of these, the maximum RR was found in a parish housing an asbestos factory [RR 10.5, 95{\%} confidence interval (CI) 5.5–19.4, environmental exposure in particular RR 2.9, 95{\%} CI 0.7–9.1]. Conclusion Non-occupational asbestos exposure is the main cause of MM and may account for up to 66{\%} of MM cases among women in North Jutland, Denmark.",
keywords = "Asbestos exposure, Asbestos industry, Hotspot, Risk for malignant mesothelioma",
author = "Vasiliki Panou and Mogens Vyberg and Christos Meristoudis and Johnni Hansen and Martin B{\o}gsted and {\O}yvind Omland and Weinreich, {Ulla M{\o}ller} and R{\o}e, {Oluf Dimitri}",
year = "2019",
month = "1",
doi = "10.5271/sjweh.3756",
language = "English",
volume = "45",
pages = "82--89",
journal = "Scandinavian Journal of Work, Environment & Health",
issn = "0355-3140",
publisher = "Tyoterveyslaitos",
number = "1",

}

TY - JOUR

T1 - Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North Jutland, Denmark

AU - Panou, Vasiliki

AU - Vyberg, Mogens

AU - Meristoudis, Christos

AU - Hansen, Johnni

AU - Bøgsted, Martin

AU - Omland, Øyvind

AU - Weinreich, Ulla Møller

AU - Røe, Oluf Dimitri

PY - 2019/1

Y1 - 2019/1

N2 - Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women with MM are scarce. This observational study aimed to elucidate the asbestos exposure patterns among women with MM. Methods All histological and cytological specimens from women diagnosed with MM between 1974–2015 at the Institute of Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational and habitation information were obtained from Danish registries and medical journals based on record linkage via the unique person ID. The number of MM cases in each parish in the region of North Jutland was determined and the incidence density in parishes was used to calculate the spatial relative risk (RR) of MM among women. Results Diagnosis of MM was confirmed in 91 women. Exposure types were classified as occupational (9%), domestic (10%), environmental (22%), combination of domestic and environmental (34%) and unknown (25%). Twenty continuous parishes formed a MM “hotspot” around the asbestos-consuming industries in the city of Aalborg. Of these, the maximum RR was found in a parish housing an asbestos factory [RR 10.5, 95% confidence interval (CI) 5.5–19.4, environmental exposure in particular RR 2.9, 95% CI 0.7–9.1]. Conclusion Non-occupational asbestos exposure is the main cause of MM and may account for up to 66% of MM cases among women in North Jutland, Denmark.

AB - Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women with MM are scarce. This observational study aimed to elucidate the asbestos exposure patterns among women with MM. Methods All histological and cytological specimens from women diagnosed with MM between 1974–2015 at the Institute of Pathology, Aalborg University Hospital in Denmark, were re-evaluated. Occupational and habitation information were obtained from Danish registries and medical journals based on record linkage via the unique person ID. The number of MM cases in each parish in the region of North Jutland was determined and the incidence density in parishes was used to calculate the spatial relative risk (RR) of MM among women. Results Diagnosis of MM was confirmed in 91 women. Exposure types were classified as occupational (9%), domestic (10%), environmental (22%), combination of domestic and environmental (34%) and unknown (25%). Twenty continuous parishes formed a MM “hotspot” around the asbestos-consuming industries in the city of Aalborg. Of these, the maximum RR was found in a parish housing an asbestos factory [RR 10.5, 95% confidence interval (CI) 5.5–19.4, environmental exposure in particular RR 2.9, 95% CI 0.7–9.1]. Conclusion Non-occupational asbestos exposure is the main cause of MM and may account for up to 66% of MM cases among women in North Jutland, Denmark.

KW - Asbestos exposure

KW - Asbestos industry

KW - Hotspot

KW - Risk for malignant mesothelioma

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U2 - 10.5271/sjweh.3756

DO - 10.5271/sjweh.3756

M3 - Journal article

VL - 45

SP - 82

EP - 89

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

SN - 0355-3140

IS - 1

ER -