On the Relationship Between Fascicle Diameter and Perineurium Thickness in the Ulnar Nerve of Pigs

Felipe Rettore Andreis, Benjamin Metcalfe, Taha Al Muhammadee Janjua, Valéria Paula Sassoli Fazan, Winnie Jensen, Suzan Meijs, Thomas Gomes Nørgaard dos Santos Nielsen

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceartikel i proceedingForskningpeer review

Abstract

The anatomical structures of peripheral nerves significantly influence the performance and selectivity of neural interfaces. Among these structures, the perineurium thickness, because of its high resistivity, is important in shaping the electric field distribution within a nerve. However, data on the perineurium thickness of somatic nerves in animals is sparse. As animal models are the first step towards developing novel implantable nerve interfaces, this study characterises the perineurium thickness in the ulnar nerve of pigs. Distal and proximal sections of the ulnar nerve (n=6) were extracted, stained with haematoxylin and eosin, and the perineurium thickness and fascicular diameters were measured. In total, 129 fascicles were quantified, and the average fascicle diameter was 269±73.3μm and 277 ± 81.1 μm for the distal and proximal nerves, respectively (p=0.59). A linear relationship was observed between fascicle diameter and perineurium thickness (R2=0.69). This relationship was affected by the location of the nerve section, with distal sections having a greater perineurium thickness than proximal segments. Finally, equations were provided to estimate the perineurium thickness based on fascicle diameter. This information can be used to develop realistic peripheral nerve models, which can reduce variability and improve the selectivity of neural interfaces.

OriginalsprogEngelsk
Titel11th International IEEE/EMBS Conference on Neural Engineering, NER 2023 - Proceedings
ForlagIEEE
Publikationsdato24 apr. 2023
Artikelnummer10123782
ISBN (Trykt)978-1-6654-6293-8
ISBN (Elektronisk)978-1-6654-6292-1
DOI
StatusUdgivet - 24 apr. 2023
Begivenhed11th International IEEE/EMBS Conference on Neural Engineering (2023 NER) - Baltimore, USA
Varighed: 24 apr. 202327 apr. 2023
https://cid.wse.jhu.edu/blog/ieee-embs-2023/

Konference

Konference11th International IEEE/EMBS Conference on Neural Engineering (2023 NER)
Land/OmrådeUSA
ByBaltimore
Periode24/04/202327/04/2023
Internetadresse
NavnInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN1948-3546

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