TY - JOUR
T1 - One-pot Reduction of Nitrostyrenes to Phenethylamines using Sodium Borohydride and Copper(II) chloride
AU - d'Andrea, Laura
PY - 2023/9/20
Y1 - 2023/9/20
N2 - The preparation of phenethylamines and phenylisoproylamines of scientific relevance can be achieved with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. The method also reduces nitrobenzene and methyl benzoate in 92 to 97% yields, respectively, while has no effect on benzoic acid, benzamide, and aromatic halides. This one-pot procedure allows the isolation of substituted β-nitrostyrene scaffolds up to 83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.
AB - The preparation of phenethylamines and phenylisoproylamines of scientific relevance can be achieved with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. The method also reduces nitrobenzene and methyl benzoate in 92 to 97% yields, respectively, while has no effect on benzoic acid, benzamide, and aromatic halides. This one-pot procedure allows the isolation of substituted β-nitrostyrene scaffolds up to 83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.
U2 - 10.26434/chemrxiv-2023-nwn3x-v4
DO - 10.26434/chemrxiv-2023-nwn3x-v4
M3 - Journal article
SN - 0022-3263
JO - The Journal of Organic Chemistry
JF - The Journal of Organic Chemistry
ER -