Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Morten Bentestuen; Camilla Sylvest; Anna Poulsgaard Frandsen; Helle D. Zacho

doi:10.1097/RLU.0000000000005586

Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Morten Bentestuen^*, Camilla Sylvest, Anna Poulsgaard Frandsen, Helle D. Zacho

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Kasuistik › Forskning › peer review

1 Citationer (Scopus)

Abstract

A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

Originalsprog	Engelsk
Tidsskrift	Clinical Nuclear Medicine
Vol/bind	50
Udgave nummer	3
Sider (fra-til)	e178-e179
Antal sider	2
ISSN	0363-9762
DOI	https://doi.org/10.1097/RLU.0000000000005586
Status	Udgivet - 1 mar. 2025

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abstract = "A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.",

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author = "Morten Bentestuen and Camilla Sylvest and Frandsen, {Anna Poulsgaard} and Zacho, {Helle D.}",

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AU - Bentestuen, Morten

AU - Sylvest, Camilla

AU - Frandsen, Anna Poulsgaard

AU - Zacho, Helle D.

PY - 2025/3/1

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N2 - A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

AB - A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18F-FDG PET/CT and 68Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68Ga-FAPI-46 PET/CT.

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KW - FDG PET/CT

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KW - ovarian neoplasms

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Ovarian Clear Cell Adenocarcinoma With Low 68Ga-FAPI-46 and Low 18F-FDG Uptake on PET/CT: A Case Report

Abstract

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