Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Morten Thorsen; Niels Bilenberg; Lena Thorsen; Tanja Maria Michel

doi:10.1007/s10803-021-04897-x

Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Morten Thorsen^*, Niels Bilenberg, Lena Thorsen, Tanja Maria Michel

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Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.

Originalsprog	Engelsk
Tidsskrift	Journal of Autism and Developmental Disorders
Vol/bind	52
Udgave nummer	1
Sider (fra-til)	275-282
Antal sider	8
ISSN	0162-3257
DOI	https://doi.org/10.1007/s10803-021-04897-x
Status	Udgivet - jan. 2022

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title = "Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study",

abstract = "Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.",

keywords = "Autism Spectrum Disorder, Oxidative Stress, Sex, Superoxide Dismutase, Xanthine Oxidase",

author = "Morten Thorsen and Niels Bilenberg and Lena Thorsen and Michel, {Tanja Maria}",

note = "{\textcopyright} 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Bilenberg, Niels

AU - Thorsen, Lena

AU - Michel, Tanja Maria

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KW - Autism Spectrum Disorder

KW - Oxidative Stress

KW - Sex

KW - Superoxide Dismutase

KW - Xanthine Oxidase

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Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study

Abstract

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