TY - JOUR
T1 - Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis in Denmark 1994-2006: A nationwide population-based study
AU - Tuckuviene, R
AU - Christensen, Anette Luther
AU - Helgestad, J
AU - Johnsen, Søren Paaske
AU - Kristensen, Søren Risom
N1 - Copyright © 2010 Foundation Acta Paediatrica.
PY - 2011
Y1 - 2011
N2 - Aim: To asses the incidence rates (IR), clinical characteristics, risk factors, treatment and outcomes of paediatric arterial ischaemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT). Methods: Using population-based, nationwide medical registries, we identified all patients aged 0-18 years at the time of hospitalization with first-ever AIS and/or CSVT in Denmark between 1994 and 2006. Medical records were retrieved and reviewed. Results: We identified 211 cases of AIS and 40 cases of CSVT corresponding to IRs of 1.33 (95% CI 1.16-1.52) and 0.25 (95% CI 0.19-0.34) per 100,000 person-years, respectively. The IRs peaked in infancy (<1year) for both AIS and CSVT with an additional peak among adolescents (15-18 years) for CSVT. The IR of AIS increased 3.9% per year (p=0.036), whereas no changes were found for CSVT. In total, 48.2% of the patients received antithrombotic treatment; no major complications were observed. All-cause and thrombosis-related 30-day case fatality ratios were 3.6% and 2.4%, respectively; neurological sequelae were found in 56.2% of patients. Conclusion: The IR of AIS was highest in infants and had increased with 3.9% annually during the observation period. The IR of CSVT had an additional peak in adolescence and remained unchanged over time.
AB - Aim: To asses the incidence rates (IR), clinical characteristics, risk factors, treatment and outcomes of paediatric arterial ischaemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT). Methods: Using population-based, nationwide medical registries, we identified all patients aged 0-18 years at the time of hospitalization with first-ever AIS and/or CSVT in Denmark between 1994 and 2006. Medical records were retrieved and reviewed. Results: We identified 211 cases of AIS and 40 cases of CSVT corresponding to IRs of 1.33 (95% CI 1.16-1.52) and 0.25 (95% CI 0.19-0.34) per 100,000 person-years, respectively. The IRs peaked in infancy (<1year) for both AIS and CSVT with an additional peak among adolescents (15-18 years) for CSVT. The IR of AIS increased 3.9% per year (p=0.036), whereas no changes were found for CSVT. In total, 48.2% of the patients received antithrombotic treatment; no major complications were observed. All-cause and thrombosis-related 30-day case fatality ratios were 3.6% and 2.4%, respectively; neurological sequelae were found in 56.2% of patients. Conclusion: The IR of AIS was highest in infants and had increased with 3.9% annually during the observation period. The IR of CSVT had an additional peak in adolescence and remained unchanged over time.
U2 - 10.1111/j.1651-2227.2010.02100.x
DO - 10.1111/j.1651-2227.2010.02100.x
M3 - Journal article
C2 - 21114523
SN - 0803-5253
VL - 100
SP - 543
EP - 549
JO - Acta Paediatrica
JF - Acta Paediatrica
IS - 4
ER -