TY - JOUR
T1 - Pain Science in Practice (Part 5)
T2 - Central Sensitization II.
AU - Hoegh, Morten
PY - 2023/2
Y1 - 2023/2
N2 -
SYNOPSIS:
Central sensitization is an umbrella-term for facilitated synaptic plasticity. This editorial explains wind-up, classical central sensitization, and long-term potentiation. Wind-up and LTP are generally considered homosynaptic, while classical central sensitization is classified as heterosynaptic. Wind-up is very short lived and unlikely to play a significant role in chronic musculoskeletal pain, however, both LTP and classical central sensitization could potentially be involved in chronic pain. J Orthop Sports Phys Ther 2023;53(2):55-58. doi:10.2519/jospt.2023.11571.
AB -
SYNOPSIS:
Central sensitization is an umbrella-term for facilitated synaptic plasticity. This editorial explains wind-up, classical central sensitization, and long-term potentiation. Wind-up and LTP are generally considered homosynaptic, while classical central sensitization is classified as heterosynaptic. Wind-up is very short lived and unlikely to play a significant role in chronic musculoskeletal pain, however, both LTP and classical central sensitization could potentially be involved in chronic pain. J Orthop Sports Phys Ther 2023;53(2):55-58. doi:10.2519/jospt.2023.11571.
KW - Central Nervous System Sensitization
KW - Chronic Pain
KW - Humans
KW - Musculoskeletal Pain
KW - Neuronal Plasticity
KW - pain
KW - central sensitization
KW - classical central sensitization
KW - wind-up
KW - long-term potentiation
UR - http://www.scopus.com/inward/record.url?scp=85147186989&partnerID=8YFLogxK
U2 - 10.2519/jospt.2023.11571
DO - 10.2519/jospt.2023.11571
M3 - Editorial
C2 - 36722100
SN - 0190-6011
VL - 53
SP - 55
EP - 58
JO - Journal of Orthopaedic and Sports Physical Therapy
JF - Journal of Orthopaedic and Sports Physical Therapy
IS - 2
ER -