TY - JOUR
T1 - Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis
T2 - A multicentre study of 1500 cases
AU - Olesen, Søren S
AU - Lisitskaya, Maria Valeryevna
AU - Drewes, Asbjørn M
AU - Novovic, Srdan
AU - Nøjgaard, Camilla
AU - Kalaitzakis, Evangelos
AU - Jensen, Nanna M
AU - Engjom, Trond
AU - Erchinger, Friedemann
AU - Waage, Anne
AU - Hauge, Truls
AU - Haas, Stephan L
AU - Vujasinovic, Miroslav
AU - Lindkvist, Björn
AU - Zviniene, Kristina
AU - Pukitis, Aldis
AU - Ozola-Zālīte, Imanta
AU - Okhlobystin, Alexey
AU - Parhiala, Mikael
AU - Laukkarinen, Johanna
AU - Frøkjær, Jens B
AU - Scandinavian Baltic Pancreatic Club
PY - 2019/10
Y1 - 2019/10
N2 - Background: Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse aetiological risk factors. Methods: This was a multicentre, cross-sectional study including 1509 patients with CP. Patient and disease characteristics were compared for patients with calcifications (n = 912) vs. without calcifications (n = 597). Multivariable logistic regression was performed to assess the parameters independently associated with calcifications. Results: The mean age of patients was 53.9 ± 14.5 years and 1006 (67%) were men. The prevalence of calcifications was 60.4% in the overall patient cohort, but highly variable between patients with different aetiological risk factors (range: 2–69%). On multivariate analysis, alcoholic aetiology (OR 1.76 [95% CI, 1.39–2.24]; p < 0.001) and smoking aetiology (OR 1.77 [95% CI, 1.39–2.26], p < 0.001) were positively associated with the presence of calcifications, while an autoimmune aetiology was negatively associated with calcifications (OR 0.15 [95% CI, 0.08–0.27], p < 0.001). Patients with pancreatic calcifications were more likely to have undergone pancreatic duct stenting (OR 1.59 [95%CI, 1.16–2.19], p = 0.004). Conclusion: The presence of pancreatic calcifications is associated with diverse aetiological risk factors in patients with CP. This observation attest to the understanding of CP as a complex disease and may have implications for disease classification.
AB - Background: Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse aetiological risk factors. Methods: This was a multicentre, cross-sectional study including 1509 patients with CP. Patient and disease characteristics were compared for patients with calcifications (n = 912) vs. without calcifications (n = 597). Multivariable logistic regression was performed to assess the parameters independently associated with calcifications. Results: The mean age of patients was 53.9 ± 14.5 years and 1006 (67%) were men. The prevalence of calcifications was 60.4% in the overall patient cohort, but highly variable between patients with different aetiological risk factors (range: 2–69%). On multivariate analysis, alcoholic aetiology (OR 1.76 [95% CI, 1.39–2.24]; p < 0.001) and smoking aetiology (OR 1.77 [95% CI, 1.39–2.26], p < 0.001) were positively associated with the presence of calcifications, while an autoimmune aetiology was negatively associated with calcifications (OR 0.15 [95% CI, 0.08–0.27], p < 0.001). Patients with pancreatic calcifications were more likely to have undergone pancreatic duct stenting (OR 1.59 [95%CI, 1.16–2.19], p = 0.004). Conclusion: The presence of pancreatic calcifications is associated with diverse aetiological risk factors in patients with CP. This observation attest to the understanding of CP as a complex disease and may have implications for disease classification.
KW - Alcohol
KW - Calcifications
KW - Chronic pancreatitis
KW - Endoscopy
KW - Smoking
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=85071077223&partnerID=8YFLogxK
U2 - 10.1016/j.pan.2019.08.009
DO - 10.1016/j.pan.2019.08.009
M3 - Journal article
C2 - 31462382
SN - 1424-3903
VL - 19
SP - 922
EP - 928
JO - Pancreatology
JF - Pancreatology
IS - 7
ER -