TY - JOUR
T1 - Pediatric Neuromyelitis Optica Spectrum Disorder
T2 - Case Series and Literature Review
AU - Ferilli, Michela Ada Noris
AU - Paparella, Roberto
AU - Morandini, Ilaria
AU - Papetti, Laura
AU - Figà Talamanca, Lorenzo
AU - Ruscitto, Claudia
AU - Ursitti, Fabiana
AU - Moavero, Romina
AU - Sforza, Giorgia
AU - Tarantino, Samuela
AU - Proietti Checchi, Martina
AU - Vigevano, Federico
AU - Valeriani, Massimiliano
PY - 2022
Y1 - 2022
N2 - Neuromyelitis Optica Spectrum Disorder (NMOSD) is a central nervous system (CNS) inflammatory demyelinating disease characterized by recurrent inflammatory events that primarily involve optic nerves and the spinal cord, but also affect other regions of the CNS, including hypothalamus, area postrema and periaqueductal gray matter. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Recently, myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG negative patients. NMOSD is rare among children and adolescents, but early diagnosis is important to start adequate therapy. In this report, we present cases of seven pediatric patients with NMOSD and we review the clinical and neuroimaging characteristics, diagnosis, and treatment of NMOSD in children.
AB - Neuromyelitis Optica Spectrum Disorder (NMOSD) is a central nervous system (CNS) inflammatory demyelinating disease characterized by recurrent inflammatory events that primarily involve optic nerves and the spinal cord, but also affect other regions of the CNS, including hypothalamus, area postrema and periaqueductal gray matter. The aquaporin-4 antibody (AQP4-IgG) is specific for NMOSD. Recently, myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) have been found in a group of AQP4-IgG negative patients. NMOSD is rare among children and adolescents, but early diagnosis is important to start adequate therapy. In this report, we present cases of seven pediatric patients with NMOSD and we review the clinical and neuroimaging characteristics, diagnosis, and treatment of NMOSD in children.
KW - Aquaporin-4 antibody
KW - Children
KW - Longitudinally extensive transverse myelitis
KW - Myelin oligodendrocyte glycoprotein antibodies
KW - Neuromyelitis optica spectrum disorder
KW - Optic neuritis
UR - http://www.scopus.com/inward/record.url?scp=85121584702&partnerID=8YFLogxK
U2 - 10.3390/life12010019
DO - 10.3390/life12010019
M3 - Review article
SN - 2075-1729
VL - 12
JO - Life
JF - Life
IS - 1
M1 - 19
ER -