@article{48c2641fa0fc45e0a2afbed64bd8e053,
title = "Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes",
abstract = "OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.",
keywords = "Body Mass Index, Chromosome Aberrations, Diabetes Mellitus, Type 1, European Continental Ancestry Group, Female, Hemoglobin A, Glycosylated, Humans, Infant, Newborn, Perinatal Mortality, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Prospective Studies, Retrospective Studies",
author = "Jensen, {Dorte M} and Lars Korsholm and Per Ovesen and Henning Beck-Nielsen and Lars Moelsted-Pedersen and Westergaard, {Jes G} and Margrethe Moeller and Peter Damm",
year = "2009",
doi = "10.2337/dc08-2061",
language = "English",
volume = "32",
pages = "1046--8",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
}