TY - JOUR
T1 - Placental baseline conditions modulate the hyperoxic BOLD-MRI response
AU - Sinding, Marianne Munk
AU - Peters, David A
AU - Poulsen, Sofie Sondrup
AU - Frøkjær, Jens Brøndum
AU - Christiansen, Ole Bjarne
AU - Petersen, Astrid Christine
AU - Uldbjerg, Niels
AU - Sørensen, Anne
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objectives Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). Method We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight < 10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative ΔBOLD response ((hyperoxic BOLD – baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute ΔT2* (hyperoxic T2*– baseline T2*) from breath-hold multi-echo GRE sequences. Results In the control group, the relative ΔBOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative ΔBOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute ΔT2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score −3.13; 95% CI -3.94, −2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log
10 ΔBOLD response and the baseline T2* (r = −0.88, p < 0.0001). Conclusion The high hyperoxic ΔBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (ΔT2*) does not differ between groups.
AB - Objectives Human pregnancies complicated by placental dysfunction may be characterized by a high hyperoxic Blood oxygen level-dependent (BOLD) MRI response. The pathophysiology behind this phenomenon remains to be established. The aim of this study was to evaluate whether it is associated with altered placental baseline conditions, including a lower oxygenation and altered tissue morphology, as estimated by the placental transverse relaxation time (T2*). Method We included 49 normal pregnancies (controls) and 13 pregnancies complicated by placental dysfunction (cases), defined by a birth weight < 10th percentile in combination with placental pathological signs of vascular malperfusion. During maternal oxygen inhalation, we measured the relative ΔBOLD response ((hyperoxic BOLD – baseline BOLD)/baseline BOLD) from a dynamic single-echo gradient-recalled echo (GRE) MRI sequence and the absolute ΔT2* (hyperoxic T2*– baseline T2*) from breath-hold multi-echo GRE sequences. Results In the control group, the relative ΔBOLD response increased during gestation from 5% in gestational week 20 to 20% in week 40. In the case group, the relative ΔBOLD response was significantly higher (mean Z-score 4.94; 95% CI 2.41, 7.47). The absolute ΔT2*, however, did not differ between controls and cases (p = 0.37), whereas the baseline T2* was lower among cases (mean Z-score −3.13; 95% CI -3.94, −2.32). Furthermore, we demonstrated a strong negative linear correlation between the Log
10 ΔBOLD response and the baseline T2* (r = −0.88, p < 0.0001). Conclusion The high hyperoxic ΔBOLD response demonstrated in pregnancies complicated by placental dysfunction may simply reflect altered baseline conditions, as the absolute increase in placental oxygenation (ΔT2*) does not differ between groups.
KW - BOLD MRI
KW - Magnetic resonance imaging
KW - Placental dysfunction
KW - Placental oxygenation
KW - T2 relaxation
UR - http://www.scopus.com/inward/record.url?scp=85034015430&partnerID=8YFLogxK
U2 - 10.1016/j.placenta.2017.11.002
DO - 10.1016/j.placenta.2017.11.002
M3 - Journal article
SN - 0143-4004
VL - 61
SP - 17
EP - 23
JO - Placenta
JF - Placenta
ER -