Platelet count kinetics following interruption of antiretroviral treatment

Eva Zetterberg, Jacqueline Neuhaus, Jason V Baker, Charurut Somboonwit, Josep M Llibre, Adrian Palfreeman, Maria Chini, Jens Lundgren, INSIGHT SMART Study Group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

11 Citationer (Scopus)

Abstract

To investigate the mechanisms of platelet kinetics in the Strategies for Management of Antiretroviral Therapy (SMART) study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) drug conservation compared with continuous treatment viral suppression. Follow-up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART.
OriginalsprogEngelsk
TidsskriftAIDS
Vol/bind27
Udgave nummer1
Sider (fra-til)59-68
Antal sider10
ISSN0269-9370
DOI
StatusUdgivet - 2 jan. 2013

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