Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk

Marie Frederiksen, Katrin Vorkamp, Jesper Bo Nielsen, Lars Schiøtt Sørensen, Marianne Thomsen, Lisbeth E. Knudsen

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

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Resumé

Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4].

Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding.

PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.

As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).

Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.

[1] Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054.
[2] Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.
[3] Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.
[4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.
[5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.
OriginalsprogEngelsk
Publikationsdato2016
Antal sider1
StatusUdgivet - 2016
BegivenhedDUST2016: 2nd International Conference on Atmospheric Dust - Nova Yardinia, Taranta, Italien
Varighed: 12 jun. 201617 jun. 2016
http://www.scientevents.com/dust2016/

Konference

KonferenceDUST2016
LokationNova Yardinia
LandItalien
ByTaranta
Periode12/06/201617/06/2016
Internetadresse

Citer dette

Frederiksen, M., Vorkamp, K., Nielsen, J. B., Sørensen, L. S., Thomsen, M., & Knudsen, L. E. (2016). Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk. Abstract fra DUST2016, Taranta, Italien.
Frederiksen, Marie ; Vorkamp, Katrin ; Nielsen, Jesper Bo ; Sørensen, Lars Schiøtt ; Thomsen, Marianne ; Knudsen, Lisbeth E. / Polybrominated diphenyl ethers and novel flame retardants : associations between dust and human milk. Abstract fra DUST2016, Taranta, Italien.1 s.
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title = "Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk",
abstract = "Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4]. Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding. PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35{\%} of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100{\%} vs. 37{\%}).Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.[1] Stapleon H.M., Eagle S., Sj{\"o}din A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054. [2] Frederiksen M., Thomsen C., Fr{\o}shaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.[3] Sahlstr{\"o}m L.M.O., Sellstr{\"o}m U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.[4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.[5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.",
author = "Marie Frederiksen and Katrin Vorkamp and Nielsen, {Jesper Bo} and S{\o}rensen, {Lars Schi{\o}tt} and Marianne Thomsen and Knudsen, {Lisbeth E.}",
year = "2016",
language = "English",
note = "null ; Conference date: 12-06-2016 Through 17-06-2016",
url = "http://www.scientevents.com/dust2016/",

}

Frederiksen, M, Vorkamp, K, Nielsen, JB, Sørensen, LS, Thomsen, M & Knudsen, LE 2016, 'Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk', DUST2016, Taranta, Italien, 12/06/2016 - 17/06/2016.

Polybrominated diphenyl ethers and novel flame retardants : associations between dust and human milk. / Frederiksen, Marie; Vorkamp, Katrin; Nielsen, Jesper Bo; Sørensen, Lars Schiøtt; Thomsen, Marianne; Knudsen, Lisbeth E.

2016. Abstract fra DUST2016, Taranta, Italien.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

TY - ABST

T1 - Polybrominated diphenyl ethers and novel flame retardants

T2 - associations between dust and human milk

AU - Frederiksen, Marie

AU - Vorkamp, Katrin

AU - Nielsen, Jesper Bo

AU - Sørensen, Lars Schiøtt

AU - Thomsen, Marianne

AU - Knudsen, Lisbeth E.

PY - 2016

Y1 - 2016

N2 - Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4]. Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding. PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.[1] Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054. [2] Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.[3] Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.[4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.[5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.

AB - Besides diet, house dust has been recognized as an important exposure media for polybrominated diphenyl ethers (PBDEs) [1]. Our previous work showed significant associations between levels in dust and in human plasma, for the congeners BDE-28, BDE-47 and BDE-100 as well as for ΣPBDEtri hexa [2]. Recent results from Sweden indicated that dust was a significant source of exposure for the octa- to decabrominated congeners in particular [3]. Moreover, several novel flame retardants (NFRs) have been detected in dust some of which might be replacement products of PBDEs [4]. Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding. PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.[1] Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054. [2] Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.[3] Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.[4] Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.[5] Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.

M3 - Conference abstract for conference

ER -

Frederiksen M, Vorkamp K, Nielsen JB, Sørensen LS, Thomsen M, Knudsen LE. Polybrominated diphenyl ethers and novel flame retardants: associations between dust and human milk. 2016. Abstract fra DUST2016, Taranta, Italien.