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Building on these findings, the objectives were to study whether i) the associations observed for plasma also existed for human milk, ii) the PBDE profiles in dust and milk could provide insights into the bioavailability and bioaccumulation of individual congeners, iii) NFRs were measurable in human milk, and iv) infants were exposed to significant amounts of NFRs via breast feeding.
PBDEs were detected in all of the 40 milk samples analysed in this study. ΣPBDEtri-hepta ranged from 0.98-45.8 ng/g lw, with a median of 2.26 ng/g lw. The main congener in milk was BDE-153, accounting for 35% of ΣPBDEtri-hepta. This is much higher than in dust collected in the same residences, but comparable to plasma and placenta [2,5]. BDE-99 on the other hand, had clearly lower percentages in human milk than in dust. BDE-209 had a median concentration of 0.64 ng/g lw, which was similar to that of BDE-47 and confirmed that BDE-209 was taken up by humans and, despite its shorter half-life, accumulates to the extent that exposure of infants can occur.
As for plasma, PBDE-levels in milk samples were significantly correlated with dust levels (Spearman rank), this was most pronounced for the lower brominated congeners like BDE-28 (p=0.03) and 47 (p=0.006). Large intercorrelation was also observed, e.g. BDE-47 in milk was significantly correlated with most other congeners, though not with BDE-209. In contrast to the plasma results, significant correlation of BDE-99 in milk and dust was also observed (p=0.003). One explanation for this may be the higher detection frequency of BDE-99 in milk compared with plasma (100% vs. 37%).
Hexabromocyclododecane and the NFRs bis(2-ethylhexyl)tetrabromophthalate (BEH-TEBP), 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB), 1,2-bis(2,4,6-tribromophenoxy)-ethane (BTBPE), decabromodiphenyl ethane (DBDPE), 2,3-dibromopropyl-2,4,6-tribromophenyl ether (TBP-DBPE) and dechlorane plus (DDC-CO) have been detected in the same dust samples previously analysed for PBDEs and are currently being analysed in the corresponding human milk samples.
 Stapleon H.M., Eagle S., Sjödin A., Webster T.F. (2012). Serum PBDEs in a North Carolina Toddler Cohort: Associations with handwipes, house dust, and socioeconomic variables. Environ. Health Perspect. 120, 1049-1054.
 Frederiksen M., Thomsen C., Frøshaug M., Vorkamp K., Thomsen M., Becher G., Knudsen L.E. (2010). Polybrominated diphenyl ethers in paired samples of maternal and umbilical cord blood plasma and associations with house dust in a Danish cohort. Int. J. Hyg. Environ. Health 213, 233-242.
 Sahlström L.M.O., Sellström U., de Wit C.A., Lignell S., Darnerud P.O. (2015). Estimated intakes of brominated flame retardants via diet and dust compared to internal concentrations in a Swedish mother-toddler cohort. Int. J. Hyg. Environ. Health 218, 422-432.
 Ali N., Harrad S., Goosey E., Neels H., Covaci A. (2011). “Novel” brominated flame retardants in Belgian and UK indoor dust: Implications for human exposure. Chemosphere 83, 1360-1365.
 Vorkamp K., Thomsen M., Frederiksen M., Pedersen M., Knudsen L.E. (2011). Polybrominated diphenyl ethers (PBDEs) in the indoor environment and associations with prenatal exposure. Environ. Int. 37, 1-10.
|Status||Udgivet - 2016|
|Begivenhed||DUST2016: 2nd International Conference on Atmospheric Dust - Nova Yardinia, Taranta, Italien|
Varighed: 12 jun. 2016 → 17 jun. 2016
|Periode||12/06/2016 → 17/06/2016|
Frederiksen, M., Sørensen, L. S., Vorkamp, K., Knudsen, L. E., Nielsen, J. B. & Webster, T.
01/01/2014 → 30/06/2016
Projekter: Projekt › ForskningFil