Abstract
Fungi produce a wide array of secondary metabolites, with interesting bioactivities by help of a number of enzyme complexes. Polyketide synthases (PKS) are
a class of multidomain enzymes, producing a class of secondary metabolites called polyketides1,2. Only few structures of PKS’s have been described, even
fewer from fungi and none from Fusarium species. Multidomain proteins can be quite challenging to work with, which is why the project intends to solve the
3D-structures of single domains of PKS’s. In this project, the plan is to clone, express and purify the Acyl-carrier protein (ACP) domain from PKS6 in Fusarium
graminearum for structural analysis.
a class of multidomain enzymes, producing a class of secondary metabolites called polyketides1,2. Only few structures of PKS’s have been described, even
fewer from fungi and none from Fusarium species. Multidomain proteins can be quite challenging to work with, which is why the project intends to solve the
3D-structures of single domains of PKS’s. In this project, the plan is to clone, express and purify the Acyl-carrier protein (ACP) domain from PKS6 in Fusarium
graminearum for structural analysis.
Originalsprog | Engelsk |
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Publikationsdato | 23 mar. 2014 |
Status | Udgivet - 23 mar. 2014 |
Begivenhed | 12 European Conference on Fungal Genetics - Seville, Spanien Varighed: 23 mar. 2014 → 28 mar. 2014 |
Konference
Konference | 12 European Conference on Fungal Genetics |
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Land/Område | Spanien |
By | Seville |
Periode | 23/03/2014 → 28/03/2014 |