TY - JOUR
T1 - Potential Usages of A-to-I RNA Editing Patterns as Diagnostic Biomarkers
AU - Rodriguez-Morales, David
AU - Ilieva, Mirolyuba
AU - Rennie, Sarah
AU - Uchida, Shizuka
PY - 2023/4
Y1 - 2023/4
N2 - Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing enzymes, adenosine deaminase acting on RNAs (ADARs), are upregulated in stressed cells and under dis-ease conditions, suggesting that monitoring RNA editing patterns might be useful as diagnostic biomarkers of various diseases. Here, we provide an overview of epitranscriptomics, and focus particularly on the detection and analysis of A-to-I RNA editing using bioinformatic tools in RNA-seq datasets, as well as briefly reviewing the existing evidence about its involvement in disease progressions. Finally, we argue for the detection of RNA editing patterns as part of the routine analysis in RNA-based datasets, with the aim of accelerating the identification of RNA editing targets linked to disease.
AB - Adenosine to inosine (A-to-I) RNA editing is one of the most frequent RNA modifications found in the mammalian transcriptome. Recent studies clearly indicate that RNA editing enzymes, adenosine deaminase acting on RNAs (ADARs), are upregulated in stressed cells and under dis-ease conditions, suggesting that monitoring RNA editing patterns might be useful as diagnostic biomarkers of various diseases. Here, we provide an overview of epitranscriptomics, and focus particularly on the detection and analysis of A-to-I RNA editing using bioinformatic tools in RNA-seq datasets, as well as briefly reviewing the existing evidence about its involvement in disease progressions. Finally, we argue for the detection of RNA editing patterns as part of the routine analysis in RNA-based datasets, with the aim of accelerating the identification of RNA editing targets linked to disease.
KW - RNA editing
KW - RNA-seq analysis
KW - diagnostic biomarkers
KW - epitranscriptomics
UR - http://www.scopus.com/inward/record.url?scp=85151312980&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00024.2023
DO - 10.1152/ajpcell.00024.2023
M3 - Review article
SN - 0363-6143
VL - 324
SP - C837-C842
JO - American Journal of Physiology: Cell Physiology
JF - American Journal of Physiology: Cell Physiology
IS - 4
ER -