Protein kinase C (PKC) may be involved in growth regulation. In the present study the relationship between body weight, and thereby age, and the activity of PKC in muscle as well as in rapidly growing overloaded muscle were investigated. PKC activity in music was linearly inversely correlated to rat weight in both soleus (r = -0.59, P < 0.05) and in plantaris (r = -0.74, P < 0.01) muscles. During compensatory hypertrophy. PKC activity per muscle was maximally increased compared with the contralateral control muscles after 4days in both soleus(126%)and in plantaris (105%) but had returned to basal levels by the 9th day. The data are in agreement with a role for PKC in muscle growth
Bibliografisk noteFunding Information:
Ac~nol~.le~ljier,fenrs:B etina Bolmgreen provided skilled technical assistance. The study was supported in part by gmnts from the Danish Natural Sciences Research Council, Grant I l-7766. The Danisb Medical Research Council, Grant 12-7424. and by the Danish Mcdjcal Association.
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