Psychiatric Disease Susceptibility and Pain in Chronic Pancreatitis: Association or Causation?

Mahya Faghih, Asbjørn M Drewes, Vikesh K Singh*


Publikation: Bidrag til tidsskriftLederpeer review


ABSTRACT: Pain perception in chronic pancreatitis (CP) is governed by the transmission of nociceptive inputs into the pain processing centers of the brain. These regions of the brain overlap with those that regulate and process emotions and cognition. Disorders in these regions also result in psychiatric conditions such as depression, anxiety, and posttraumatic stress disorder. The present study by Dunbar et al. evaluated 24 single nucleotide polymorphisms associated with anxiety and/or posttraumatic stress disorder and found correlations with constant and severe pain phenotypes in CP patients from a large cross-sectional cohort study. Although causation cannot be proven, the findings suggest that there may be a role for neuromodulator drugs for the treatment of pain in CP based on individual genetic susceptibility.

TidsskriftThe American Journal of Gastroenterology
Udgave nummer10
Sider (fra-til)2026-2028
Antal sider3
StatusUdgivet - 1 okt. 2021

Bibliografisk note

Copyright © 2021 by The American College of Gastroenterology.


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