Abstract
In 10 patients with chronic plaque type psoriasis one or two plaques affected equally with psoriasis were chosen for study. Five punched out rings of a hydrocolloid dressing were applied to the psoriasis plaque(s). In each circular test area 20 mg of one of the following creams was applied: base, 1% hydrocortisone (DAK), 0.1% triamcinolone acetonide (Kenalogue), 0.1% betamethasone-17-valerate cream (Betnovate), and 0.05% clobetasol proprionate cream (Dermovate). The areas were occluded with a thin film of transparent hydrocolloid dressing (Comfeel Transparent Dressing), for 1 week. Non-invasive measurements (ultrasound skin thickness, laser-Doppler flowmetry, colorimetry) were performed before and after treatment. Therapeutic response was evaluated blindly by clinical score. The measurements showed a decline in blood flow, a decrease in skin thickness, and normalization of colour approaching that of normal skin, the more potent the corticosteroid used. The clinical scores showed the same: the more potent a corticosteroid used, the closer to the score of normal skin. Data on variability and applications of the methods are presented. The study concludes that potent corticosteroids occluded with a hydrocolloid dressing can clear psoriasis in 1 week. Short-course corticosteroid therapy appears harmless and relevant for clinical dermatology.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Clinical and Experimental Dermatology |
Vol/bind | 15 |
Udgave nummer | 5 |
Sider (fra-til) | 343-8 |
Antal sider | 6 |
ISSN | 0307-6938 |
DOI | |
Status | Udgivet - 1990 |
Udgivet eksternt | Ja |
Emneord
- Administration, Topical
- Adult
- Aged
- Anti-Inflammatory Agents
- Bandages, Hydrocolloid
- Betamethasone Valerate
- Clobetasol
- Colloids
- Female
- Glucocorticoids
- Humans
- Hydrocortisone
- Male
- Middle Aged
- Occlusive Dressings
- Psoriasis
- Skin
- Time Factors
- Triamcinolone Acetonide