Recent advancements in antibiotics removal by bio-electrochemical systems (BESs): From mechanisms to application of emerging combined systems

Recent advancements in bio-electrochemical systems (BESs) for antibiotic removal are receiving great attentions due to the electro-active bacteria on the electrode that could elevate the removal efficiency. Enhanced detoxification performance of BESs compared to the traditional biological processes indicates the great potential serving as a sustainable alternative or a pre-/post-processing unit to improve the performance of biological processes. However, the successfully application of BESs to antibiotic-polluted water remediation requires a deeper discussion on their operational performance and emerging coupled systems. In order to address BESs as a practical option for antibiotic removal, we deeply analyze the detoxification mechanism of antibiotic treatment by BESs, involving BES fundamentals, extracellular electron transfer and degradation pathways via functional enzymes of microorganisms, followed by systematic evaluations of the operational conditions. Furthermore, the recently-emerged BESs combined with other techniques for practical applications has been summarized and emphasized. This review further directions the current limitations such as the potential risk of antibiotic resistance genes, etc., and prospects for the attenuation of antibiotics via BESs related techniques, promoting the development of practical application.