TY - JOUR
T1 - Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Linseisen, Jakob
AU - Grundmann, Nina
AU - Zoller, Dorothee
AU - Kühn, Tilman
AU - Jansen, Eugène H J M
AU - Chajès, Veronique
AU - Fedirko, Veronika
AU - Weiderpass, Elisabete
AU - Dahm, Christina C
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Boutron-Ruault, Marie-Christine
AU - Rothwell, Joseph A
AU - Severi, Gianluca
AU - Kaaks, Rudolf
AU - Schulze, Matthias B
AU - Aleksandrova, Krasimira
AU - Sieri, Sabina
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Masala, Giovanna
AU - De Marco, Laura
AU - Bueno-de-Mesquita, Bas
AU - Vermeulen, Roel
AU - Gram, Inger T
AU - Skeie, Guri
AU - Chirlaque, María-Dolores
AU - Ardanaz, Eva
AU - Agudo, Antonio
AU - Sánchez, Maria-José
AU - Amiano, Pilar
AU - Wennberg, Maria
AU - Bodén, Stina
AU - Perez-Cornago, Aurora
AU - Aglago, Elom K
AU - Gunter, Marc J
AU - Jenab, Mazda
AU - Heath, Alicia K
AU - Nieters, Alexandra
N1 - ©2021 American Association for Cancer Research.
PY - 2021/5
Y1 - 2021/5
N2 - BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.METHODS: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models.RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR = 1.23; 95% CI = 1.07-1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.CONCLUSIONS: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk.IMPACT: These findings add to the evidence on colorectal cancer prevention.
AB - BACKGROUND: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.METHODS: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models.RESULTS: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR = 1.23; 95% CI = 1.07-1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.CONCLUSIONS: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk.IMPACT: These findings add to the evidence on colorectal cancer prevention.
UR - http://www.scopus.com/inward/record.url?scp=85105474619&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-20-1426
DO - 10.1158/1055-9965.EPI-20-1426
M3 - Journal article
C2 - 33619024
SN - 1055-9965
VL - 30
SP - 874
EP - 885
JO - Cancer Epidemiology, Biomarkers & Prevention
JF - Cancer Epidemiology, Biomarkers & Prevention
IS - 5
ER -