Regulation of glycogen synthesis in rat skeletal muscle after glycogen-depleting contractile activity: Effects of adrenaline on glycogen synthesis and activation of glycogen synthase and glycogen phosphorylase

Jesper Franch, Rune Aslesen, Jørgen Jensen*

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Abstract

We investigated the effects of insulin and adrenaline on the rate of glycogen synthesis in skeletal muscles after electrical stimulation in vitro. The contractile activity decreased the glycogen concentration by 62%. After contractile activity, the glycogen stores were fully replenished at a constant and high rate for 3 h when 10 m-i.u./ml insulin was present. In the absence of insulin, only 65% of the initial glycogen stores was replenished. Adrenaline decreased insulin-stimulated glycogen synthesis. Surprisingly, adrenaline did not inhibit glycogen synthesis stimulated by glycogen-depleting contractile activity. In agreement with this, the fractional activity of glycogen synthase was high when adrenaline was present after exercise, whereas adrenaline decreased the fractional activity of glycogen synthase to a low level during stimulation with insulin. Furthermore, adrenaline activated glycogen phosphorylase almost completely during stimulation with insulin whereas a much lower activation of glycogen phosphorylase was observed after contractile activity. Thus adrenaline does not inhibit contraction-stimulated glycogen synthesis.

OriginalsprogEngelsk
TidsskriftBiochemical Journal
Vol/bind344
Udgave nummer1
Sider (fra-til)231-235
Antal sider5
ISSN0264-6021
DOI
StatusUdgivet - 15 nov. 1999

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Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

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