TY - JOUR
T1 - Relationship between treatment of erectile dysfunction and future risk of cardiovascular disease
T2 - A nationwide cohort study
AU - Jensen, Nanna Vestergaard
AU - Søgaard, Peter
AU - Torp-Pedersen, Christian
AU - Aasbjerg, Kristian
PY - 2017
Y1 - 2017
N2 - Aims Erectile dysfunction is associated with increased risk of cardiovascular disease; however, little is known about patients seeking treatment for erectile dysfunction. This study investigated the risk of cardiovascular disease for patients receiving medication for erectile dysfunction. Methods and results This nationwide cohort study included 71,710 men aged 40-80 years receiving their first erectile dysfunction medication from 2000 to 2012. Their adjusted risk of cardiovascular events in time intervals after the first erectile dysfunction medication was compared to the general male population using multivariate Poisson regression models and was expressed as a risk ratio (RR). The risk for overall cardiovascular disease was decreased in the first 3 years: the RR in the first year was 0.92 (95% confidence interval [CI] 0.87-0.97, p = 0.003; incidence: 23.68 per 1000 patient-years), and after 1-3 years the RR was 0.94 (95% CI 0.90-0.97, p = 0.002; incidence: 24.92 per 1000 patient-years). After 3 years, there was no significant difference. The risk of myocardial infarction was decreased in all time intervals: the RR in the first year was 0.60 (95% CI 0.50-0.73, p < 0.001; incidence: 1.82 per 1000 patient-years), after 1-3 years the RR was 0.72 (95% CI 0.63-0.82, p < 0.001; incidence: 2.16 per 1000 patient-years) and after 3 years the RR was 0.80 (95% CI 0.73-0.88, p < 0.001; incidence: 2.25 per 1000 patient-years). The risk of heart failure was decreased in the first 3 years. Conclusion Receiving medication for erectile dysfunction was associated with a decreased risk of myocardial infarction and cardiovascular diseases for the first 3 years.
AB - Aims Erectile dysfunction is associated with increased risk of cardiovascular disease; however, little is known about patients seeking treatment for erectile dysfunction. This study investigated the risk of cardiovascular disease for patients receiving medication for erectile dysfunction. Methods and results This nationwide cohort study included 71,710 men aged 40-80 years receiving their first erectile dysfunction medication from 2000 to 2012. Their adjusted risk of cardiovascular events in time intervals after the first erectile dysfunction medication was compared to the general male population using multivariate Poisson regression models and was expressed as a risk ratio (RR). The risk for overall cardiovascular disease was decreased in the first 3 years: the RR in the first year was 0.92 (95% confidence interval [CI] 0.87-0.97, p = 0.003; incidence: 23.68 per 1000 patient-years), and after 1-3 years the RR was 0.94 (95% CI 0.90-0.97, p = 0.002; incidence: 24.92 per 1000 patient-years). After 3 years, there was no significant difference. The risk of myocardial infarction was decreased in all time intervals: the RR in the first year was 0.60 (95% CI 0.50-0.73, p < 0.001; incidence: 1.82 per 1000 patient-years), after 1-3 years the RR was 0.72 (95% CI 0.63-0.82, p < 0.001; incidence: 2.16 per 1000 patient-years) and after 3 years the RR was 0.80 (95% CI 0.73-0.88, p < 0.001; incidence: 2.25 per 1000 patient-years). The risk of heart failure was decreased in the first 3 years. Conclusion Receiving medication for erectile dysfunction was associated with a decreased risk of myocardial infarction and cardiovascular diseases for the first 3 years.
KW - Journal Article
U2 - 10.1177/2047487317718082
DO - 10.1177/2047487317718082
M3 - Journal article
C2 - 28656785
SN - 2047-4873
VL - 24
SP - 1498
EP - 1505
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 14
M1 - 2047487317718082
ER -