Reversibility of acute intermediate phase bilirubin encephalopathy

Thor Willy Ruud Hansen; Lutz Nietsch; Elisabeth Norman; Jesper Vandborg Bjerre; Jean-Michel Hascoet; Khalaf Mreihil; Finn Ebbesen

doi:10.1111/j.1651-2227.2009.01409.x

Reversibility of acute intermediate phase bilirubin encephalopathy

Thor Willy Ruud Hansen, Lutz Nietsch, Elisabeth Norman, Jesper Vandborg Bjerre, Jean-Michel Hascoet, Khalaf Mreihil, Finn Ebbesen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

63 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Oct

Originalsprog	Engelsk
Tidsskrift	Acta Paediatrica
Vol/bind	98
Sider (fra-til)	1689-94
Antal sider	5
ISSN	0803-5253
DOI	https://doi.org/10.1111/j.1651-2227.2009.01409.x
Status	Udgivet - 2009
Udgivet eksternt	Ja

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10.1111/j.1651-2227.2009.01409.x

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Citationsformater

@article{400d24783e3e4243b06b549c14695d9f,

title = "Reversibility of acute intermediate phase bilirubin encephalopathy",

abstract = "AIM: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. METHODS: Case studies. RESULTS: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal. CONCLUSIONS: Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.",

keywords = "Acute Disease, Bilirubin, Combined Modality Therapy, Exchange Transfusion, Whole Blood, Female, Globus Pallidus, Humans, Immunoglobulins, Intravenous, Infant, Newborn, Jaundice, Neonatal, Kernicterus, Magnetic Resonance Imaging, Male, Phototherapy",

author = "Hansen, {Thor Willy Ruud} and Lutz Nietsch and Elisabeth Norman and Bjerre, {Jesper Vandborg} and Jean-Michel Hascoet and Khalaf Mreihil and Finn Ebbesen",

year = "2009",

doi = "10.1111/j.1651-2227.2009.01409.x",

language = "English",

volume = "98",

pages = "1689--94",

journal = "Acta Paediatrica",

issn = "0803-5253",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Reversibility of acute intermediate phase bilirubin encephalopathy

AU - Hansen, Thor Willy Ruud

AU - Nietsch, Lutz

AU - Norman, Elisabeth

AU - Bjerre, Jesper Vandborg

AU - Hascoet, Jean-Michel

AU - Mreihil, Khalaf

AU - Ebbesen, Finn

PY - 2009

Y1 - 2009

N2 - AIM: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. METHODS: Case studies. RESULTS: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal. CONCLUSIONS: Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.

AB - AIM: To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy. METHODS: Case studies. RESULTS: Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal. CONCLUSIONS: Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.

KW - Acute Disease

KW - Bilirubin

KW - Combined Modality Therapy

KW - Exchange Transfusion, Whole Blood

KW - Female

KW - Globus Pallidus

KW - Humans

KW - Immunoglobulins, Intravenous

KW - Infant, Newborn

KW - Jaundice, Neonatal

KW - Kernicterus

KW - Magnetic Resonance Imaging

KW - Male

KW - Phototherapy

U2 - 10.1111/j.1651-2227.2009.01409.x

DO - 10.1111/j.1651-2227.2009.01409.x

M3 - Journal article

SN - 0803-5253

VL - 98

SP - 1689

EP - 1694

JO - Acta Paediatrica

JF - Acta Paediatrica

ER -

Reversibility of acute intermediate phase bilirubin encephalopathy

Abstract

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