Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results

J. S. Jensen; Anders Galløe; Jens F Lassen; Andrejs Erglis; Indulis Kumsars; Terje K Steigen; Rune Wiseth; Inga Narbute; Pål Gunnes; Jan Mannsverk; Oliver Meyerdierks; Svein Rotevatn; Matti Niemelä; Kari Kervinen; Kjell Nikus; Saila Vikman; Jan Ravkilde; Stefan James; Jens Aarøe; Antti Ylitalo; Steffen Helqvist; Iwar Sjögren; Per Thayssen; Kari Virtanen; Mikko Puhakka; Juhani Airaksinen; Leif Thuesen; Nordic-Baltic PCI Study Group

Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results

J. S. Jensen, Anders Galløe, Jens F Lassen, Andrejs Erglis, Indulis Kumsars, Terje K Steigen, Rune Wiseth, Inga Narbute, Pål Gunnes, Jan Mannsverk, Oliver Meyerdierks, Svein Rotevatn, Matti Niemelä, Kari Kervinen, Kjell Nikus, Saila Vikman, Jan Ravkilde, Stefan James, Jens Aarøe, Antti YlitaloSteffen Helqvist, Iwar Sjögren, Per Thayssen, Kari Virtanen, Mikko Puhakka, Juhani Airaksinen, Leif Thuesen, Nordic-Baltic PCI Study Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

58 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Aug

Originalsprog	Engelsk
Vol/bind	4
Sider (fra-til)	229-33
Antal sider	4
ISSN	1774-024X
Status	Udgivet - 2008
Udgivet eksternt	Ja

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Citationsformater

Jensen, J. S., Galløe, A., Lassen, J. F., Erglis, A., Kumsars, I., Steigen, T. K., Wiseth, R., Narbute, I., Gunnes, P., Mannsverk, J., Meyerdierks, O., Rotevatn, S., Niemelä, M., Kervinen, K., Nikus, K., Vikman, S., Ravkilde, J., James, S., Aarøe, J., ... Nordic-Baltic PCI Study Group (2008). Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results. 4, 229-33.

@article{3c8a6b0c0bec471ca79045bc611befe3,

title = "Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results",

abstract = "AIMS: The risk of stent thrombosis has been reported to increase with percutaneous coronary intervention (PCI) complexity. The present study reports the pre-specified secondary endpoint of a 14-month stent thrombosis and major adverse cardiac events in patients stented with a simple versus a complex bifurcation technique using sirolimus eluting stents (SES). METHODS AND RESULTS: A total of 413 patients with a coronary bifurcation lesion were randomised to a simple treatment strategy; stenting of main vessel and optional stenting of side branch (MV group), or to a complex stenting strategy; stenting of both main vessel and side branch (MV+SB group). Mortality data were available in all patients and 14-month clinical follow-up data in 395 (96%) of the patients. After 14 months, the rates of definite, probable and possible stent thrombosis (ARC criteria) were 1.0% vs. 0.5%, 1.0% vs. 0% and 0.5% vs. 0% (ns) in the MV and in the MV+SB groups, respectively. Rates of MACE were 9.5% in the MV group and 8.2% in the MV+SB group (ns). Total death was seen in 2.4% vs. 1.0% and non-PCI related myocardial infarction in 2.0% vs. 1.0% in the MV and the MV+SB groups, respectively. CONCLUSIONS: After 14 months, two months after recommended cessation of dual antiplatelet therapy, the rates of stent thrombosis and major adverse cardiac events were low and independent of treatment complexity in patients treated with SES for coronary artery bifurcation lesions.",

author = "Jensen, {J. S.} and Anders Gall{\o}e and Lassen, {Jens F} and Andrejs Erglis and Indulis Kumsars and Steigen, {Terje K} and Rune Wiseth and Inga Narbute and P{\aa}l Gunnes and Jan Mannsverk and Oliver Meyerdierks and Svein Rotevatn and Matti Niemel{\"a} and Kari Kervinen and Kjell Nikus and Saila Vikman and Jan Ravkilde and Stefan James and Jens Aar{\o}e and Antti Ylitalo and Steffen Helqvist and Iwar Sj{\"o}gren and Per Thayssen and Kari Virtanen and Mikko Puhakka and Juhani Airaksinen and Leif Thuesen and {Nordic-Baltic PCI Study Group}",

year = "2008",

language = "English",

volume = "4",

pages = "229--33",

issn = "1774-024X",

publisher = "Europa Digital & Publishing",

}

Jensen, JS, Galløe, A, Lassen, JF, Erglis, A, Kumsars, I, Steigen, TK, Wiseth, R, Narbute, I, Gunnes, P, Mannsverk, J, Meyerdierks, O, Rotevatn, S, Niemelä, M, Kervinen, K, Nikus, K, Vikman, S, Ravkilde, J, James, S, Aarøe, J, Ylitalo, A, Helqvist, S, Sjögren, I, Thayssen, P, Virtanen, K, Puhakka, M, Airaksinen, J, Thuesen, L & Nordic-Baltic PCI Study Group 2008, 'Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results', bind 4, s. 229-33.

TY - JOUR

T1 - Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results

AU - Jensen, J. S.

AU - Galløe, Anders

AU - Lassen, Jens F

AU - Erglis, Andrejs

AU - Kumsars, Indulis

AU - Steigen, Terje K

AU - Wiseth, Rune

AU - Narbute, Inga

AU - Gunnes, Pål

AU - Mannsverk, Jan

AU - Meyerdierks, Oliver

AU - Rotevatn, Svein

AU - Niemelä, Matti

AU - Kervinen, Kari

AU - Nikus, Kjell

AU - Vikman, Saila

AU - Ravkilde, Jan

AU - James, Stefan

AU - Aarøe, Jens

AU - Ylitalo, Antti

AU - Helqvist, Steffen

AU - Sjögren, Iwar

AU - Thayssen, Per

AU - Virtanen, Kari

AU - Puhakka, Mikko

AU - Airaksinen, Juhani

AU - Thuesen, Leif

AU - Nordic-Baltic PCI Study Group

PY - 2008

Y1 - 2008

N2 - AIMS: The risk of stent thrombosis has been reported to increase with percutaneous coronary intervention (PCI) complexity. The present study reports the pre-specified secondary endpoint of a 14-month stent thrombosis and major adverse cardiac events in patients stented with a simple versus a complex bifurcation technique using sirolimus eluting stents (SES). METHODS AND RESULTS: A total of 413 patients with a coronary bifurcation lesion were randomised to a simple treatment strategy; stenting of main vessel and optional stenting of side branch (MV group), or to a complex stenting strategy; stenting of both main vessel and side branch (MV+SB group). Mortality data were available in all patients and 14-month clinical follow-up data in 395 (96%) of the patients. After 14 months, the rates of definite, probable and possible stent thrombosis (ARC criteria) were 1.0% vs. 0.5%, 1.0% vs. 0% and 0.5% vs. 0% (ns) in the MV and in the MV+SB groups, respectively. Rates of MACE were 9.5% in the MV group and 8.2% in the MV+SB group (ns). Total death was seen in 2.4% vs. 1.0% and non-PCI related myocardial infarction in 2.0% vs. 1.0% in the MV and the MV+SB groups, respectively. CONCLUSIONS: After 14 months, two months after recommended cessation of dual antiplatelet therapy, the rates of stent thrombosis and major adverse cardiac events were low and independent of treatment complexity in patients treated with SES for coronary artery bifurcation lesions.

AB - AIMS: The risk of stent thrombosis has been reported to increase with percutaneous coronary intervention (PCI) complexity. The present study reports the pre-specified secondary endpoint of a 14-month stent thrombosis and major adverse cardiac events in patients stented with a simple versus a complex bifurcation technique using sirolimus eluting stents (SES). METHODS AND RESULTS: A total of 413 patients with a coronary bifurcation lesion were randomised to a simple treatment strategy; stenting of main vessel and optional stenting of side branch (MV group), or to a complex stenting strategy; stenting of both main vessel and side branch (MV+SB group). Mortality data were available in all patients and 14-month clinical follow-up data in 395 (96%) of the patients. After 14 months, the rates of definite, probable and possible stent thrombosis (ARC criteria) were 1.0% vs. 0.5%, 1.0% vs. 0% and 0.5% vs. 0% (ns) in the MV and in the MV+SB groups, respectively. Rates of MACE were 9.5% in the MV group and 8.2% in the MV+SB group (ns). Total death was seen in 2.4% vs. 1.0% and non-PCI related myocardial infarction in 2.0% vs. 1.0% in the MV and the MV+SB groups, respectively. CONCLUSIONS: After 14 months, two months after recommended cessation of dual antiplatelet therapy, the rates of stent thrombosis and major adverse cardiac events were low and independent of treatment complexity in patients treated with SES for coronary artery bifurcation lesions.

M3 - Journal article

SN - 1774-024X

VL - 4

SP - 229

EP - 233

ER -

Safety in simple versus complex stenting of coronary artery bifurcation lesions. The nordic bifurcation study 14-month follow-up results

Abstract

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