TY - JOUR
T1 - Salivary gland carcinoma in Denmark
T2 - a national update and follow-up on incidence, histology, and outcome
AU - Westergaard-Nielsen, Marie
AU - Godballe, Christian
AU - Eriksen, Jesper Grau
AU - Larsen, Stine Rosenkilde
AU - Kiss, Katalin
AU - Agander, Tina
AU - Ulhøi, Benedicte Parm
AU - Charabi, Birgitte
AU - Klug, Tejs Ehlers
AU - Jacobsen, Henrik
AU - Johansen, Jørgen
AU - Kristensen, Claus Andrup
AU - Andersen, Elo
AU - Andersen, Maria
AU - Andreasen, Simon
AU - Bjørndal, Kristine
PY - 2021/4
Y1 - 2021/4
N2 - Purpose: Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods: Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results: The study population consisted of 769 men and 832 women, median age 62 years (range 6–102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion: The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.
AB - Purpose: Salivary gland carcinoma is a rare disease and studies on epidemiology and outcome require data collection over many years. The aim of this study is to present an update of incidence rates, anatomical sites, histological subtypes, and survival rates based on the Danish national cohort of salivary gland carcinoma patients. Methods: Data from all Danish patients with salivary gland carcinoma diagnosed from 1990 to 2015 (n = 1601) were included and analyzed following histological reevaluation and reclassification. Overall, disease-specific, and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression. Results: The study population consisted of 769 men and 832 women, median age 62 years (range 6–102). The most frequent anatomic site was the parotid gland (51.8%). Adenoid cystic carcinoma was the most common subtype (24.7%). The majority had tumor classification T1/T2 (65.3%). The mean crude incidence was 1.2/100.000/year with an increase of 1.5% per year. There was no increase in age-adjusted incidence. The 5-, 10-, and 20-year survival rates were for overall survival 68, 52, and 35%, for disease-specific survival, 77, 69, and 64%, and for recurrence-free survival, 75, 64, and 51%, respectively. Age, high-grade histological subtype, advanced T-classification, cervical lymph node metastases, vascular invasion, and involved surgical margins had significantly negative impact on survival rates. Conclusion: The age-adjusted incidence has been stable for a period of 26 years. Multivariate analysis confirmed that histological grade, advanced stage, involved surgical margins and vascular invasion are independent negative prognostic factors. Survival rates were stationary compared to earlier reports.
KW - Histological subtypes
KW - Incidence
KW - Prognostic factors
KW - Salivary gland carcinoma
KW - Survival rates
UR - http://www.scopus.com/inward/record.url?scp=85088248430&partnerID=8YFLogxK
U2 - 10.1007/s00405-020-06205-2
DO - 10.1007/s00405-020-06205-2
M3 - Journal article
AN - SCOPUS:85088248430
SN - 0937-4477
VL - 278
SP - 1179
EP - 1188
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 4
ER -