TY - JOUR
T1 - Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study
T2 - Study Protocol for a Multinational Population-Based Consecutive Cohort
AU - Bartek Jiri, Jr
AU - Laugesen, Christian
AU - Mirza, Sadia
AU - Forsse, Axel
AU - Petersen, Michael Anders
AU - Corell, Alba
AU - Dyhrfort, Philip Wilhelm
AU - Redebrandt, Henrietta Nittby
AU - Reen, Linus
AU - Zolfaghari, Shaian
AU - Tobieson, Lovisa
AU - Carlsvärd, Björn
AU - Bergholt, Bo
AU - Bashir, Asma
AU - Soerensen, Preben
AU - Bilgin, Arzu
AU - Johansson, Conny
AU - Lindvall, Peter
AU - Förander, Petter
AU - Bellander, Bo-Michael
AU - Springborg, Jacob B
AU - Jakola, Asgeir S
PY - 2019/3
Y1 - 2019/3
N2 - BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved. OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables. METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190. EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified. DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.
AB - BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved. OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables. METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190. EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified. DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.
KW - Acute subdural hematoma
KW - Elderly
KW - Outcome
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=85061593542&partnerID=8YFLogxK
U2 - 10.1093/neuros/nyy173
DO - 10.1093/neuros/nyy173
M3 - Journal article
SN - 0148-396X
VL - 84
SP - 799
EP - 803
JO - Neurosurgery
JF - Neurosurgery
IS - 3
ER -