TY - JOUR
T1 - Seasonality, incidence and prognosis in atrial fibrillation and stroke in Denmark and New Zealand
AU - Christensen, Anette Luther
AU - Rasmussen, Lars Hvilsted
AU - Baker, Michael G.
AU - Lip, Gregory Y. H.
AU - Dethlefsen, Claus
AU - Larsen, Torben Bjerregaard
PY - 2012
Y1 - 2012
N2 - Objectives: There are relatively few large studies of seasonal variation in the occurrence of stroke in patients with atrial fibrillation (AF). We investigated the seasonal variation in incidence rates of hospitalisation with stroke in patients from Denmark and New Zealand. Design: Cohort study. Setting: Nationwide hospital discharge data from Denmark and New Zealand. Participants: 243 381 (median age 75) subjects having a first-time hospitalisation with AF in Denmark and 51 480 (median age 76) subjects in New Zealand constituted the study population. Subjects with previous hospitalisation with stroke were excluded. Primary and secondary effect measures: Peak-to-trough ratio of the seasonal variation in incidence rates of stroke in AF patients adjusted for an overall trend was primary effect measure and was assessed using a log-linear Poisson regression model. Secondary effect measures were incidence rate ratios of AF and 30-day case fatality for stroke patients. Results: Incidence rates of AF per 1000 person-years in Denmark increased by 5.4% (95% CI 5.3% to 5.7%) for patients aged
AB - Objectives: There are relatively few large studies of seasonal variation in the occurrence of stroke in patients with atrial fibrillation (AF). We investigated the seasonal variation in incidence rates of hospitalisation with stroke in patients from Denmark and New Zealand. Design: Cohort study. Setting: Nationwide hospital discharge data from Denmark and New Zealand. Participants: 243 381 (median age 75) subjects having a first-time hospitalisation with AF in Denmark and 51 480 (median age 76) subjects in New Zealand constituted the study population. Subjects with previous hospitalisation with stroke were excluded. Primary and secondary effect measures: Peak-to-trough ratio of the seasonal variation in incidence rates of stroke in AF patients adjusted for an overall trend was primary effect measure and was assessed using a log-linear Poisson regression model. Secondary effect measures were incidence rate ratios of AF and 30-day case fatality for stroke patients. Results: Incidence rates of AF per 1000 person-years in Denmark increased by 5.4% (95% CI 5.3% to 5.7%) for patients aged
UR - http://www.scopus.com/inward/record.url?scp=84865971312&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2012-001210
DO - 10.1136/bmjopen-2012-001210
M3 - Journal article
AN - SCOPUS:84865971312
SN - 2044-6055
VL - 2
JO - BMJ Open
JF - BMJ Open
IS - 4
M1 - 001210
ER -