TY - JOUR
T1 - Sensitization Symptoms are Associated with Psychological and Cognitive Variables in COVID-19 Survivors Exhibiting post-COVID Pain
AU - Fernández-de-las-Peñas, César
AU - Parás-Bravo, Paula
AU - Ferrer-Pargada, Diego
AU - Cancela-Cilleruelo, Ignacio
AU - Rodríguez-Jiménez, Jorge
AU - Nijs, Jo
AU - Arendt-Nielsen, Lars
AU - Herrero-Montes, Manuel
N1 - Funding: Proyecto financiado por la convocatoria Next-Val 2021 de la Fundación
Instituto de Investigación Marqués de Valdecilla (IDIVAL) and by a grant from the Novo Nordisk Foundation 0067235.
© 2022 World Institute of Pain.
PY - 2023/1
Y1 - 2023/1
N2 - Objective: To investigate the association between demographic, clinical, psychological, cognitive, and health-related variables and the Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors exhibiting “de novo” post-COVID pain. Methods: Seventy-seven (n = 77) COVID-19 survivors with “de novo” post-COVID pain completed demographic (age, height, and weight), clinical (duration and intensity of the pain), psychological (depressive/anxiety levels and sleep quality), cognitive (catastrophizing and kinesiophobia levels), and health-related quality of life variables as well as the CSI. A multivariable correlation analysis was conducted to determine the association between variables, and a stepwise multiple linear regression model was performed to identify CSI predictors. Results: Patients were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. Twenty-six (33.7%) individuals showed indications of sensitization-associated symptoms (CSI score ≥40 points). The CSI score was positively associated with pain intensity (r: 0.371), anxiety (r: 0.784), depressive (r: 0.709), catastrophizing (r: 0.620), and kinesiophobia (r: 0.359) levels (all, p < 0.001). The stepwise regression analysis revealed that 60.2% of CSI was explained by anxiety levels and pain intensity. Conclusion: This study found that psychological and cognitive variables were associated with the CSI score in previously hospitalized COVID-19 survivors with “de novo” post-COVID pain. Anxiety levels and the intensity of pain symptoms were independently associated with CSI score suggesting a significant overlap with psychological construct. The “de novo” post-COVID pain association with CSI may indicate changes in the pain processing important for managing the pain.
AB - Objective: To investigate the association between demographic, clinical, psychological, cognitive, and health-related variables and the Central Sensitization Inventory (CSI) in previously hospitalized COVID-19 survivors exhibiting “de novo” post-COVID pain. Methods: Seventy-seven (n = 77) COVID-19 survivors with “de novo” post-COVID pain completed demographic (age, height, and weight), clinical (duration and intensity of the pain), psychological (depressive/anxiety levels and sleep quality), cognitive (catastrophizing and kinesiophobia levels), and health-related quality of life variables as well as the CSI. A multivariable correlation analysis was conducted to determine the association between variables, and a stepwise multiple linear regression model was performed to identify CSI predictors. Results: Patients were assessed a mean of 6.0 (SD 0.8) months after hospital discharge. Twenty-six (33.7%) individuals showed indications of sensitization-associated symptoms (CSI score ≥40 points). The CSI score was positively associated with pain intensity (r: 0.371), anxiety (r: 0.784), depressive (r: 0.709), catastrophizing (r: 0.620), and kinesiophobia (r: 0.359) levels (all, p < 0.001). The stepwise regression analysis revealed that 60.2% of CSI was explained by anxiety levels and pain intensity. Conclusion: This study found that psychological and cognitive variables were associated with the CSI score in previously hospitalized COVID-19 survivors with “de novo” post-COVID pain. Anxiety levels and the intensity of pain symptoms were independently associated with CSI score suggesting a significant overlap with psychological construct. The “de novo” post-COVID pain association with CSI may indicate changes in the pain processing important for managing the pain.
KW - COVID-19
KW - pain
KW - post-COVID
KW - sensitization
KW - anxiety
KW - COVID-19
KW - pain
KW - post-covid
KW - Sensitization
KW - anxiety
KW - sensitization
KW - post-COVID
UR - http://www.scopus.com/inward/record.url?scp=85133313771&partnerID=8YFLogxK
U2 - 10.1111/papr.13146
DO - 10.1111/papr.13146
M3 - Journal article
C2 - 35757896
SN - 1530-7085
VL - 23
SP - 23
EP - 31
JO - Pain Practice
JF - Pain Practice
IS - 1
ER -