Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients

Katja Venborg Pedersen, Donghua Liao, Susanne Sloth Osther, Asbjørn Mohr Drewes, Hans Gregersen, Palle Jörn Sloth Osther

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

Resumé

The pathogenesis of symptoms in urolithiasis is poorly understood. Traditionally increased endoluminal pressure is considered the main mechanism causing pain in the upper urinary tract but clinical data are sparse. The aim of the present study was to develop a new model related to mechanosensation in order to describe the geometric and mechanical properties of the renal pelvis in patients with kidney stone disease. Pressure measurement in the renal pelvis was done during CT-pyelography in 15 patients who underwent percutaneus nephrolithotomy. The sensory intensity was recorded at the thresholds for first sensation and for pain. 3D deformation and strain were calculated in five patients. The deformation of pelvis during distension was not uniform due to the complex geometry. The pelvis deformed to 113 ± 6% and 115 ± 11% in the longitudinal and circumferential directions, respectively. Endoluminal pressure in the renal pelvis corresponded positively to the sensory ratings but the referred pain area was diffuse located and varied in size. The present study provides a method for describing the mechanosensory properties and 3D deformation of the complex renal pelvis geometry. Although there was a relation between pressure and pain score, the non-homogenous spatial strain distribution suggests that the 3D biomechanical properties of the renal pelvis are not reflected by simple estimates of tension based on pressure and volume.
OriginalsprogEngelsk
Publikationsdato2011
StatusUdgivet - 2011
Udgivet eksterntJa
Begivenhed7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII - Hamburg
Varighed: 21 sep. 201124 sep. 2011
http://www.efic.org/index.asp?sub=OEHX4PUHZ063B4

Konference

Konference7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII
ByHamburg
Periode21/09/201124/09/2011
Internetadresse

Fingerprint

Kidney Pelvis
Kidney Calculi
Pressure
Pelvis
Pain
Referred Pain
Urolithiasis
Urography
Kidney Diseases
Urinary Tract

Citer dette

Pedersen, K. V., Liao, D., Osther, S. S., Drewes, A. M., Gregersen, H., & Osther, P. J. S. (2011). Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .
Pedersen, Katja Venborg ; Liao, Donghua ; Osther, Susanne Sloth ; Drewes, Asbjørn Mohr ; Gregersen, Hans ; Osther, Palle Jörn Sloth. / Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .
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title = "Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients",
abstract = "The pathogenesis of symptoms in urolithiasis is poorly understood. Traditionally increased endoluminal pressure is considered the main mechanism causing pain in the upper urinary tract but clinical data are sparse. The aim of the present study was to develop a new model related to mechanosensation in order to describe the geometric and mechanical properties of the renal pelvis in patients with kidney stone disease. Pressure measurement in the renal pelvis was done during CT-pyelography in 15 patients who underwent percutaneus nephrolithotomy. The sensory intensity was recorded at the thresholds for first sensation and for pain. 3D deformation and strain were calculated in five patients. The deformation of pelvis during distension was not uniform due to the complex geometry. The pelvis deformed to 113 ± 6{\%} and 115 ± 11{\%} in the longitudinal and circumferential directions, respectively. Endoluminal pressure in the renal pelvis corresponded positively to the sensory ratings but the referred pain area was diffuse located and varied in size. The present study provides a method for describing the mechanosensory properties and 3D deformation of the complex renal pelvis geometry. Although there was a relation between pressure and pain score, the non-homogenous spatial strain distribution suggests that the 3D biomechanical properties of the renal pelvis are not reflected by simple estimates of tension based on pressure and volume.",
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Pedersen, KV, Liao, D, Osther, SS, Drewes, AM, Gregersen, H & Osther, PJS 2011, 'Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients' 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, 21/09/2011 - 24/09/2011, .

Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients. / Pedersen, Katja Venborg; Liao, Donghua; Osther, Susanne Sloth; Drewes, Asbjørn Mohr; Gregersen, Hans; Osther, Palle Jörn Sloth.

2011. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskningpeer review

TY - ABST

T1 - Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients

AU - Pedersen, Katja Venborg

AU - Liao, Donghua

AU - Osther, Susanne Sloth

AU - Drewes, Asbjørn Mohr

AU - Gregersen, Hans

AU - Osther, Palle Jörn Sloth

PY - 2011

Y1 - 2011

N2 - The pathogenesis of symptoms in urolithiasis is poorly understood. Traditionally increased endoluminal pressure is considered the main mechanism causing pain in the upper urinary tract but clinical data are sparse. The aim of the present study was to develop a new model related to mechanosensation in order to describe the geometric and mechanical properties of the renal pelvis in patients with kidney stone disease. Pressure measurement in the renal pelvis was done during CT-pyelography in 15 patients who underwent percutaneus nephrolithotomy. The sensory intensity was recorded at the thresholds for first sensation and for pain. 3D deformation and strain were calculated in five patients. The deformation of pelvis during distension was not uniform due to the complex geometry. The pelvis deformed to 113 ± 6% and 115 ± 11% in the longitudinal and circumferential directions, respectively. Endoluminal pressure in the renal pelvis corresponded positively to the sensory ratings but the referred pain area was diffuse located and varied in size. The present study provides a method for describing the mechanosensory properties and 3D deformation of the complex renal pelvis geometry. Although there was a relation between pressure and pain score, the non-homogenous spatial strain distribution suggests that the 3D biomechanical properties of the renal pelvis are not reflected by simple estimates of tension based on pressure and volume.

AB - The pathogenesis of symptoms in urolithiasis is poorly understood. Traditionally increased endoluminal pressure is considered the main mechanism causing pain in the upper urinary tract but clinical data are sparse. The aim of the present study was to develop a new model related to mechanosensation in order to describe the geometric and mechanical properties of the renal pelvis in patients with kidney stone disease. Pressure measurement in the renal pelvis was done during CT-pyelography in 15 patients who underwent percutaneus nephrolithotomy. The sensory intensity was recorded at the thresholds for first sensation and for pain. 3D deformation and strain were calculated in five patients. The deformation of pelvis during distension was not uniform due to the complex geometry. The pelvis deformed to 113 ± 6% and 115 ± 11% in the longitudinal and circumferential directions, respectively. Endoluminal pressure in the renal pelvis corresponded positively to the sensory ratings but the referred pain area was diffuse located and varied in size. The present study provides a method for describing the mechanosensory properties and 3D deformation of the complex renal pelvis geometry. Although there was a relation between pressure and pain score, the non-homogenous spatial strain distribution suggests that the 3D biomechanical properties of the renal pelvis are not reflected by simple estimates of tension based on pressure and volume.

M3 - Conference abstract for conference

ER -

Pedersen KV, Liao D, Osther SS, Drewes AM, Gregersen H, Osther PJS. Sensory and biomechanical responses to distension of the renal pelvis in kidney stone patients. 2011. Abstract fra 7th Congress of the European Federation of IASP Chapters (EFIC) - PAIN IN EUROPE VII, Hamburg, .