Simultaneous occurrence of fetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature

Ellen Taaning, Lise Jensen, Kim Varming

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

6 Citationer (Scopus)

Abstract

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia due to maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding due to maternal anti-HPA-3a alloantibodies and mild neutropenia due to maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions. Conclusion:  This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays. © 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
OriginalsprogEngelsk
TidsskriftActa Paediatrica
Vol/bind101
Sider (fra-til)896-9
Antal sider4
ISSN0803-5253
DOI
StatusUdgivet - 2012
Udgivet eksterntJa

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