Solar insolation in springtime influences age of onset of bipolar I disorder

M Bauer, Tasha Glenn, M Alda, M A Aleksandrovich, O A Andreassen, E Angelopoulos, Raffaella Ardau, Y Ayhan, Christopher Baethge, S R Bharathram, R. Bauer, Bernhard T Baune, C Becerra-Palars, Frank Bellivier, R H Belmaker, Michael Berk, Yuly Bersudsky, Ş Bicakci, H Birabwa-Oketcho, T D BjellaLetizia Bossini, Juan Cabrera, Eric Yat Wo Cheung, Maria Del Zompo, Seetal Dodd, M Donix, Bruno Etain, Andrea Fagiolini, Konstantinos N Fountoulakis, Mark A Frye, Ana González-Pinto, J F Gottlieb, P Grof, Hirohiko Harima, J. C. Henry, E T Isometsä, S Janno, Flávio Kapczinski, M Kardell, S Khaldi, S Kliwicki, B. König-Ries, T L Kot, Rikke Krogh, Miriam Kunz, Beny Lafer, Mikael Landén, E R Larsen, Ute Lewitzka, R W Licht, Carlos Lopez-Jaramillo, Glenda M MacQueen, M Manchia, W Marsh, M Martinez-Cengotitabengoa, I Melle, F Meza-Urzúa, M Yee Ming, Scott Monteith, Gunnar Morken, E Mosca, Rodrigo Munoz, S V Mythri, F Nacef, R K Nadella, F G Nery, R E Nielsen, Michael C O'Donovan, A Omrani, Yamima Osher, Helle Østermark Sørensen, U Ouali, Y Pica Ruiz, M Pilhatsch, M Pinna, F D R da Ponte, D Quiroz, Rajkumar Ramesar, N Rasgon, M S Reddy, Andreas Reif, Peter Ritter, Janusz K Rybakowski, Kemal Sagduyu, Ângela M Scippa, W E Severus, C Simhandl, Dan J. Stein, S Strejilevich, M Subramaniam, Ahmad H Sulaiman, Kirsi Suominen, H Tagata, Yoshitaka Tatebayashi, Leonardo Tondo, C Torrent, A E Vaaler, J Veeh, E. Vieta, Biju Viswanath, M Yoldi-Negrete, Mark Zetin, Y Zgueb, Peter C Whybrow

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26 Citationer (Scopus)

Abstract

OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.

METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density.

RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001).

CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind136
Udgave nummer6
Sider (fra-til)571-582
Antal sider12
ISSN0001-690X
DOI
StatusUdgivet - 2017

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