Projekter pr. år
Urethral stricture is a common urinary tract disorder in men that can be caused by iatrogenic causes, trauma, inflammation, or infection and often requires reconstructive surgery. The current therapeutic approach for complex urethral strictures usually involves reconstruction with autologous tissue from the oral mucosa. With the goal of overcoming the lack of sufficient autologous tissue and donor site morbidity, research over the past two decades has focused on cell-based tissue-engineered substitutes. While the main focus has been on autologous cells from the penile tissue, bladder, and oral cavity, stem cells from sources such as adipose tissue and urine are competing candidates for future urethral regeneration due to their ease of collection, high proliferative capacity, maturation potential, and paracrine function. This review addresses the sources, advantages, and limitations of cells for tissue engineering in the urethra and discusses recent approaches to improve cell survival, growth, and differentiation by mimicking the mechanical and biophysical properties of the extracellular environment.
|Tidsskrift||International Journal of Molecular Sciences|
|Status||Udgivet - 15 nov. 2022|
FingeraftrykDyk ned i forskningsemnerne om 'Sources, Selection, and Microenvironmental Preconditioning of Cells for Urethral Tissue Engineering'. Sammen danner de et unikt fingeraftryk.
- 1 Afsluttet
Development of a 3D-printed model of the urethra to improve the treatment of stricture disease
Pennisi, P., Zachar, V. & Xuan, Z.
Hartmann Fonden, Grosserer L.F. Foghts Fond
01/10/2018 → 31/12/2022
Projekter: Projekt › Forskning