Stochastic filtering of quantitative data from STR DNA analysis

Torben Tvedebrink; Poul Svante Eriksen; Helle Smidt Mogensen; Niels Morling

Stochastic filtering of quantitative data from STR DNA analysis

Torben Tvedebrink, Poul Svante Eriksen, Helle Smidt Mogensen, Niels Morling

Institut for Matematiske Fag

Publikation: Konferencebidrag uden forlag/tidsskrift › Poster › Forskning

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Abstract

The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:

Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).

We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

Originalsprog	Engelsk
Publikationsdato	2009
Antal sider	1
Status	Udgivet - 2009
Begivenhed	ICFIS 2008 (International Conference on Forensic Inference and Statistics) - Lausanne, Schweiz Varighed: 20 aug. 2008 → 23 aug. 2008 Konferencens nummer: 7

Konference

Konference	ICFIS 2008 (International Conference on Forensic Inference and Statistics)
Nummer	7
Land/Område	Schweiz
By	Lausanne
Periode	20/08/2008 → 23/08/2008

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title = "Stochastic filtering of quantitative data from STR DNA analysis",

abstract = "The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.",

author = "Torben Tvedebrink and Eriksen, {Poul Svante} and Mogensen, {Helle Smidt} and Niels Morling",

year = "2009",

language = "English",

note = "ICFIS 2008 (International Conference on Forensic Inference and Statistics) ; Conference date: 20-08-2008 Through 23-08-2008",

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TY - CONF

T1 - Stochastic filtering of quantitative data from STR DNA analysis

AU - Tvedebrink, Torben

AU - Eriksen, Poul Svante

AU - Mogensen, Helle Smidt

AU - Morling, Niels

N1 - Conference code: 7

PY - 2009

Y1 - 2009

N2 - The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

AB - The quantitative data observed from analysing STR DNA is a mixture of contributions from various sources. Apart from the true allelic peaks, the observed signal consists of at least three components resulting from the measurement technique and the PCR amplification:Background noise (random noise due to the apparatus used for measurements).Pull-up effects (more systematic increase caused by overlap in the spectrum)Stutters (peaks located four basepairs before the true peak).We present filtering techniques for all three technical artifacts based on statistical analysis of data from controlled experiments conducted at The Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health Sciences, Universityof Copenhagen, Denmark.

M3 - Poster

T2 - ICFIS 2008 (International Conference on Forensic Inference and Statistics)

Y2 - 20 August 2008 through 23 August 2008

ER -

Stochastic filtering of quantitative data from STR DNA analysis

Abstract

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