TY - JOUR
T1 - Structural imaging findings are related to clinical complications in chronic pancreatitis
AU - Nordaas, Ingrid Kvåle
AU - Tjora, Erling
AU - Dimcevski, Georg
AU - Haldorsen, Ingfrid S.
AU - Olesen, Søren Schou
AU - Drewes, Asbjørn Mohr
AU - Zviniene, Kristina
AU - Barauskas, Giedrius
AU - Bayram, Berivan Kyed
AU - Nørregaard, Peter
AU - Borch, Anders
AU - Nøjgaard, Camilla
AU - Jensen, Annette Bøjer
AU - Kardasheva, Svetlana S.
AU - Okhlobystin, Alexey
AU - Hauge, Truls
AU - Waage, Anne
AU - Frøkjær, Jens Brøndum
AU - Engjom, Trond
AU - Scandinavian Baltic Pancreatic Club
N1 - © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.
PY - 2022/5
Y1 - 2022/5
N2 - BACKGROUND/OBJECTIVES: Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic morphology and clinical complications in a large chronic pancreatitis cohort.METHODS: The Scandinavian Baltic Pancreatic Club database collects registrations on patients with definite or probable chronic pancreatitis according to the M-ANNHEIM diagnostic criteria. In this cross-sectional study, we used multivariate logistic regression analyses to evaluate whether imaging-based structural pancreatic changes were associated with common clinical complications. We adjusted for sex, age, disease duration, current alcohol abuse and current smoking.RESULTS: We included 742 patients with a mean age of 55 years. Among these, 68% were males, 69% had pancreatic exocrine insufficiency, 35% had diabetes, 12% were underweighted and 68% reported abdominal pain. Main pancreatic duct obstruction, severe (i.e. more than 14) calcifications, pancreatic atrophy and parenchymal changes throughout the entire pancreas (continuous organ involvement) were positively associated with pancreatic exocrine insufficiency. Continuous organ involvement and pseudocysts were positively and negatively associated with diabetes, respectively. Pancreatic atrophy and severe calcifications were positively associated with underweight, and severe calcifications were negatively associated with pain.CONCLUSIONS: This study shows independent associations between distinct structural changes on pancreatic imaging and clinical complications in chronic pancreatitis. Pancreatic atrophy, severe calcifications and continuous organ involvement may be of particular clinical relevance, and these findings should motivate monitoring of pancreatic function and nutritional status.
AB - BACKGROUND/OBJECTIVES: Structural pancreatic changes and complications related to chronic pancreatitis are well described, but little is known about their relationship. We aimed to explore the associations between pancreatic morphology and clinical complications in a large chronic pancreatitis cohort.METHODS: The Scandinavian Baltic Pancreatic Club database collects registrations on patients with definite or probable chronic pancreatitis according to the M-ANNHEIM diagnostic criteria. In this cross-sectional study, we used multivariate logistic regression analyses to evaluate whether imaging-based structural pancreatic changes were associated with common clinical complications. We adjusted for sex, age, disease duration, current alcohol abuse and current smoking.RESULTS: We included 742 patients with a mean age of 55 years. Among these, 68% were males, 69% had pancreatic exocrine insufficiency, 35% had diabetes, 12% were underweighted and 68% reported abdominal pain. Main pancreatic duct obstruction, severe (i.e. more than 14) calcifications, pancreatic atrophy and parenchymal changes throughout the entire pancreas (continuous organ involvement) were positively associated with pancreatic exocrine insufficiency. Continuous organ involvement and pseudocysts were positively and negatively associated with diabetes, respectively. Pancreatic atrophy and severe calcifications were positively associated with underweight, and severe calcifications were negatively associated with pain.CONCLUSIONS: This study shows independent associations between distinct structural changes on pancreatic imaging and clinical complications in chronic pancreatitis. Pancreatic atrophy, severe calcifications and continuous organ involvement may be of particular clinical relevance, and these findings should motivate monitoring of pancreatic function and nutritional status.
KW - diabetes mellitus
KW - exocrine pancreatic insufficiency
KW - pain
KW - pancreas
KW - underweight
KW - Exocrine Pancreatic Insufficiency/diagnostic imaging
KW - Cross-Sectional Studies
KW - Humans
KW - Middle Aged
KW - Male
KW - Pancreatitis, Chronic/diagnosis
KW - Atrophy/complications
KW - Diabetes Mellitus
KW - Abdominal Pain/diagnosis
KW - Pancreatic Diseases
KW - Female
U2 - 10.1002/ueg2.12228
DO - 10.1002/ueg2.12228
M3 - Journal article
C2 - 35396813
SN - 2050-6406
VL - 10
SP - 385
EP - 395
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
IS - 4
ER -