Surgical treatment of the neck in patients with salivary gland carcinoma

Marie Westergaard-Nielsen; Christian Godballe; Jesper Grau Eriksen; Stine Rosenkilde Larsen; Katalin Kiss; Tina Agander; Benedicte Parm Ulhøi; Birgitte Wittenborg Charabi; Tejs Ehlers Klug; Henrik Jacobsen; Jørgen Johansen; Claus Andrup Kristensen; Elo Andersen; Maria Andersen; Kristine Bjørndal

doi:10.1002/hed.26667

Surgical treatment of the neck in patients with salivary gland carcinoma

Marie Westergaard-Nielsen^*, Christian Godballe, Jesper Grau Eriksen, Stine Rosenkilde Larsen, Katalin Kiss, Tina Agander, Benedicte Parm Ulhøi, Birgitte Wittenborg Charabi, Tejs Ehlers Klug, Henrik Jacobsen, Jørgen Johansen, Claus Andrup Kristensen, Elo Andersen, Maria Andersen, Kristine Bjørndal

^*Kontaktforfatter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

8 Downloads (Pure)

Abstract

Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines. Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carcinoma were treated with END. Variables potentially associated with regional metastases were analyzed using logistic regression. Neck recurrence-free survival was calculated using the Kaplan–Meier method. Results: Occult metastases were found in 36 of the patients treated with END (14%) and were particularly frequent among patients with T3/T4 tumors and high-grade histology tumors. In multivariate analyses, high-grade histology and vascular invasion were associated with occult metastases. Conclusion: We recommend END of levels II and III for patients with high-grade or unknown histological grade tumors, and for T3/T4 tumors. Levels I, II, and III should be included in END in patients with submandibular, sublingual, or minor salivary gland carcinomas.

Originalsprog	Engelsk
Tidsskrift	Head and Neck
Vol/bind	43
Udgave nummer	6
Sider (fra-til)	1898-1911
Antal sider	14
ISSN	1043-3074
DOI	https://doi.org/10.1002/hed.26667
Status	Udgivet - jun. 2021

Bibliografisk note

Funding Information:
The study was supported by the Danish Head and Neck Cancer Group (DAHANCA) and by OPEN, Odense Patient data Explorative Network, Odense University Hospital, Denmark. Special acknowledgement to Simon Andreasen (deceased) and Annelise Krogdahl for their assistance with histological specimens. The study was supported by PhD research grants from the University of Southern Denmark, the Region of Southern Denmark, the Danish Cancer Research Fund, and the Danish Cancer Society. This work was approved by all the affiliated institutions.

Publisher Copyright:
© 2021 Wiley Periodicals LLC.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Adgang til dokumentet

10.1002/hed.26667

Accepted ManuscriptAccepteret manuskript, 580 KB

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Andre filer og links

Link to publication in Scopus

Citationsformater

Westergaard-Nielsen, M., Godballe, C., Grau Eriksen, J., Larsen, S. R., Kiss, K., Agander, T., Parm Ulhøi, B., Wittenborg Charabi, B., Ehlers Klug, T., Jacobsen, H., Johansen, J., Kristensen, C. A., Andersen, E., Andersen, M., & Bjørndal, K. (2021). Surgical treatment of the neck in patients with salivary gland carcinoma. Head and Neck, 43(6), 1898-1911. Advance online publication. https://doi.org/10.1002/hed.26667

@article{6724577a354e4e8c8b941d7c54f96a27,

title = "Surgical treatment of the neck in patients with salivary gland carcinoma",

abstract = "Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines. Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carcinoma were treated with END. Variables potentially associated with regional metastases were analyzed using logistic regression. Neck recurrence-free survival was calculated using the Kaplan–Meier method. Results: Occult metastases were found in 36 of the patients treated with END (14%) and were particularly frequent among patients with T3/T4 tumors and high-grade histology tumors. In multivariate analyses, high-grade histology and vascular invasion were associated with occult metastases. Conclusion: We recommend END of levels II and III for patients with high-grade or unknown histological grade tumors, and for T3/T4 tumors. Levels I, II, and III should be included in END in patients with submandibular, sublingual, or minor salivary gland carcinomas.",

keywords = "cervical lymph nodes, neck dissection, regional metastases, salivary gland carcinoma, surgery",

author = "Marie Westergaard-Nielsen and Christian Godballe and {Grau Eriksen}, Jesper and Larsen, {Stine Rosenkilde} and Katalin Kiss and Tina Agander and {Parm Ulh{\o}i}, Benedicte and {Wittenborg Charabi}, Birgitte and {Ehlers Klug}, Tejs and Henrik Jacobsen and J{\o}rgen Johansen and Kristensen, {Claus Andrup} and Elo Andersen and Maria Andersen and Kristine Bj{\o}rndal",

note = "Funding information: Dansk Kr{\ae}ftforsknings Fond; Kr{\ae}ftens Bek{\ae}mpelse; Region of Southern Denmark; Syddansk Universitet",

year = "2021",

month = jun,

doi = "10.1002/hed.26667",

language = "English",

volume = "43",

pages = "1898--1911",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

number = "6",

}

Westergaard-Nielsen, M, Godballe, C, Grau Eriksen, J, Larsen, SR, Kiss, K, Agander, T, Parm Ulhøi, B, Wittenborg Charabi, B, Ehlers Klug, T, Jacobsen, H, Johansen, J, Kristensen, CA, Andersen, E, Andersen, M & Bjørndal, K 2021, 'Surgical treatment of the neck in patients with salivary gland carcinoma', Head and Neck, bind 43, nr. 6, s. 1898-1911. https://doi.org/10.1002/hed.26667

TY - JOUR

T1 - Surgical treatment of the neck in patients with salivary gland carcinoma

AU - Westergaard-Nielsen, Marie

AU - Godballe, Christian

AU - Grau Eriksen, Jesper

AU - Larsen, Stine Rosenkilde

AU - Kiss, Katalin

AU - Agander, Tina

AU - Parm Ulhøi, Benedicte

AU - Wittenborg Charabi, Birgitte

AU - Ehlers Klug, Tejs

AU - Jacobsen, Henrik

AU - Johansen, Jørgen

AU - Kristensen, Claus Andrup

AU - Andersen, Elo

AU - Andersen, Maria

AU - Bjørndal, Kristine

N1 - Funding information: Dansk Kræftforsknings Fond; Kræftens Bekæmpelse; Region of Southern Denmark; Syddansk Universitet

PY - 2021/6

Y1 - 2021/6

N2 - Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines. Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carcinoma were treated with END. Variables potentially associated with regional metastases were analyzed using logistic regression. Neck recurrence-free survival was calculated using the Kaplan–Meier method. Results: Occult metastases were found in 36 of the patients treated with END (14%) and were particularly frequent among patients with T3/T4 tumors and high-grade histology tumors. In multivariate analyses, high-grade histology and vascular invasion were associated with occult metastases. Conclusion: We recommend END of levels II and III for patients with high-grade or unknown histological grade tumors, and for T3/T4 tumors. Levels I, II, and III should be included in END in patients with submandibular, sublingual, or minor salivary gland carcinomas.

AB - Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines. Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carcinoma were treated with END. Variables potentially associated with regional metastases were analyzed using logistic regression. Neck recurrence-free survival was calculated using the Kaplan–Meier method. Results: Occult metastases were found in 36 of the patients treated with END (14%) and were particularly frequent among patients with T3/T4 tumors and high-grade histology tumors. In multivariate analyses, high-grade histology and vascular invasion were associated with occult metastases. Conclusion: We recommend END of levels II and III for patients with high-grade or unknown histological grade tumors, and for T3/T4 tumors. Levels I, II, and III should be included in END in patients with submandibular, sublingual, or minor salivary gland carcinomas.

KW - cervical lymph nodes

KW - neck dissection

KW - regional metastases

KW - salivary gland carcinoma

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=85102624075&partnerID=8YFLogxK

U2 - 10.1002/hed.26667

DO - 10.1002/hed.26667

M3 - Journal article

AN - SCOPUS:85102624075

SN - 1043-3074

VL - 43

SP - 1898

EP - 1911

JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Surgical treatment of the neck in patients with salivary gland carcinoma

Abstract

Bibliografisk note

Adgang til dokumentet

AUB Link

Andre filer og links

Fingeraftryk

Citationsformater