Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Kirstine Stochholm, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cliius Nielsen, Kim Brixen, Anja Lisbeth Frederiksen, Christian Godballe

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Resumé

Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.

OriginalsprogEngelsk
TidsskriftThyroid
Vol/bind29
Udgave nummer3
Sider (fra-til)368-377
Antal sider10
ISSN1050-7256
DOI
StatusUdgivet - mar. 2019

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Denmark
Confidence Intervals
Survival
Neoplasm Metastasis
Population
Medullary Thyroid cancer
Cohort Studies
Multivariate Analysis
Retrospective Studies
Lymph Nodes
Odds Ratio

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Mathiesen, Jes Sloth ; Kroustrup, Jens Peter ; Vestergaard, Peter ; Poulsen, Per Løgstrup ; Stochholm, Kirstine ; Rasmussen, Åse Krogh ; Feldt-Rasmussen, Ulla ; Schytte, Sten ; Londero, Stefano Christian ; Pedersen, Henrik Baymler ; Hahn, Christoffer Holst ; Bentzen, Jens ; Möller, Sören ; Gaustadnes, Mette ; Rossing, Maria ; Nielsen, Finn Cliius ; Brixen, Kim ; Frederiksen, Anja Lisbeth ; Godballe, Christian. / Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014 : A nationwide study. I: Thyroid. 2019 ; Bind 29, Nr. 3. s. 368-377.
@article{26acd14bb9104dffb750db5bb4de6ab9,
title = "Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study",
abstract = "Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.",
keywords = "Denmark, biochemical cure, medullary thyroid carcinoma, nationwide, population-based, survival",
author = "Mathiesen, {Jes Sloth} and Kroustrup, {Jens Peter} and Peter Vestergaard and Poulsen, {Per L{\o}gstrup} and Kirstine Stochholm and Rasmussen, {{\AA}se Krogh} and Ulla Feldt-Rasmussen and Sten Schytte and Londero, {Stefano Christian} and Pedersen, {Henrik Baymler} and Hahn, {Christoffer Holst} and Jens Bentzen and S{\"o}ren M{\"o}ller and Mette Gaustadnes and Maria Rossing and Nielsen, {Finn Cliius} and Kim Brixen and Frederiksen, {Anja Lisbeth} and Christian Godballe",
year = "2019",
month = "3",
doi = "10.1089/thy.2018.0564",
language = "English",
volume = "29",
pages = "368--377",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

Mathiesen, JS, Kroustrup, JP, Vestergaard, P, Poulsen, PL, Stochholm, K, Rasmussen, ÅK, Feldt-Rasmussen, U, Schytte, S, Londero, SC, Pedersen, HB, Hahn, CH, Bentzen, J, Möller, S, Gaustadnes, M, Rossing, M, Nielsen, FC, Brixen, K, Frederiksen, AL & Godballe, C 2019, 'Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014: A nationwide study', Thyroid, bind 29, nr. 3, s. 368-377. https://doi.org/10.1089/thy.2018.0564

Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014 : A nationwide study. / Mathiesen, Jes Sloth; Kroustrup, Jens Peter; Vestergaard, Peter; Poulsen, Per Løgstrup; Stochholm, Kirstine; Rasmussen, Åse Krogh; Feldt-Rasmussen, Ulla; Schytte, Sten; Londero, Stefano Christian; Pedersen, Henrik Baymler; Hahn, Christoffer Holst; Bentzen, Jens; Möller, Sören; Gaustadnes, Mette; Rossing, Maria; Nielsen, Finn Cliius; Brixen, Kim; Frederiksen, Anja Lisbeth; Godballe, Christian.

I: Thyroid, Bind 29, Nr. 3, 03.2019, s. 368-377.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Survival and long-term biochemical cure in medullary thyroid carcinoma in Denmark 1997-2014

T2 - A nationwide study

AU - Mathiesen, Jes Sloth

AU - Kroustrup, Jens Peter

AU - Vestergaard, Peter

AU - Poulsen, Per Løgstrup

AU - Stochholm, Kirstine

AU - Rasmussen, Åse Krogh

AU - Feldt-Rasmussen, Ulla

AU - Schytte, Sten

AU - Londero, Stefano Christian

AU - Pedersen, Henrik Baymler

AU - Hahn, Christoffer Holst

AU - Bentzen, Jens

AU - Möller, Sören

AU - Gaustadnes, Mette

AU - Rossing, Maria

AU - Nielsen, Finn Cliius

AU - Brixen, Kim

AU - Frederiksen, Anja Lisbeth

AU - Godballe, Christian

PY - 2019/3

Y1 - 2019/3

N2 - Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.

AB - Background: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients are nonexistent at a population level. A nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014 was conducted, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure. Methods: The study included 220 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. As a representative sample of the general population, a reference population matched 50:1 to the MTC cohort was used. Results: Patients diagnosed with hereditary MTC by screening (hazard ratio [HR] = 1.5 [confidence interval (CI) 0.5-4.3]), patients without regional metastases (HR = 1.4 [CI 0.9-2.3]), and patients with stage I (HR = 1.3 [CI 0.6-3.1]), stage II (HR = 1.1 [CI 0.6-2.3]), and III (HR = 1.3 [CI 0.4-4.2]) disease had an overall survival similar to the reference population. On multivariate analysis, the presence of distant metastases (HR = 12.3 [CI 6.0-25.0]) predicted worse disease-specific survival, while the absence of regional lymph node metastases (odds ratio = 40.1 [CI 12.0-133.7]) was the only independent prognostic factor for long-term biochemical cure. Conclusions: Patients with hereditary MTC diagnosed by screening, patients without regional metastases, and patients with stages I, II, and III disease may have similar survival as the general population. The presence of distant metastases predicted worse disease-specific survival, while the absence of regional metastases predicted long-term biochemical cure.

KW - Denmark

KW - biochemical cure

KW - medullary thyroid carcinoma

KW - nationwide

KW - population-based

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85060182145&partnerID=8YFLogxK

U2 - 10.1089/thy.2018.0564

DO - 10.1089/thy.2018.0564

M3 - Journal article

C2 - 30618340

VL - 29

SP - 368

EP - 377

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 3

ER -