Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C-Methyleneribonucleotides

Patrick J. Hrdlicka; T.S. Kumar; Jesper Wengel

doi:10.1002/ejoc.200500379

Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C-Methyleneribonucleotides

Patrick J. Hrdlicka
, T.S. Kumar
, Jesper Wengel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

Incorporation of conformationally restricted 3′‐C‐ethynyl‐3′‐O,4′‐C‐methyleneribonucleotide X monomers into oligodeoxyribonucleotides results in large decreases in affinity towards complementary DNA, whereas significantly more stable duplexes are formed with RNA complements. RNA selectivity becomes more pronounced upon multiple incorporations of X monomers. Increased thermal stability is observed upon positioning of two X monomers in a +1 zipper interstrand motif. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

Originalsprog	Engelsk
Tidsskrift	European Journal of Organic Chemistry
Vol/bind	2005
Udgave nummer	24
Sider (fra-til)	5184-5188
ISSN	1434-193X
DOI	https://doi.org/10.1002/ejoc.200500379
Status	Udgivet - 2005
Udgivet eksternt	Ja

Adgang til dokumentet

10.1002/ejoc.200500379

AUB Link

Søg efter materialet i Aalborg Universitetsbiblioteks søgemaskine

Citationsformater

@article{8eb8054a7f0a4e2faeb6c082c2d9a17d,

title = "Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C-Methyleneribonucleotides",

abstract = "Incorporation of conformationally restricted 3′‐C‐ethynyl‐3′‐O,4′‐C‐methyleneribonucleotide X monomers into oligodeoxyribonucleotides results in large decreases in affinity towards complementary DNA, whereas significantly more stable duplexes are formed with RNA complements. RNA selectivity becomes more pronounced upon multiple incorporations of X monomers. Increased thermal stability is observed upon positioning of two X monomers in a +1 zipper interstrand motif. ({\textcopyright} Wiley‐VCH Verlag GmbH \& Co. KGaA, 69451 Weinheim, Germany, 2005)",

author = "Hrdlicka, \{Patrick J.\} and T.S. Kumar and Jesper Wengel",

year = "2005",

doi = "10.1002/ejoc.200500379",

language = "English",

volume = "2005",

pages = "5184--5188",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH",

number = "24",

}

TY - JOUR

T1 - Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C-Methyleneribonucleotides

AU - Hrdlicka, Patrick J.

AU - Kumar, T.S.

AU - Wengel, Jesper

PY - 2005

Y1 - 2005

N2 - Incorporation of conformationally restricted 3′‐C‐ethynyl‐3′‐O,4′‐C‐methyleneribonucleotide X monomers into oligodeoxyribonucleotides results in large decreases in affinity towards complementary DNA, whereas significantly more stable duplexes are formed with RNA complements. RNA selectivity becomes more pronounced upon multiple incorporations of X monomers. Increased thermal stability is observed upon positioning of two X monomers in a +1 zipper interstrand motif. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

AB - Incorporation of conformationally restricted 3′‐C‐ethynyl‐3′‐O,4′‐C‐methyleneribonucleotide X monomers into oligodeoxyribonucleotides results in large decreases in affinity towards complementary DNA, whereas significantly more stable duplexes are formed with RNA complements. RNA selectivity becomes more pronounced upon multiple incorporations of X monomers. Increased thermal stability is observed upon positioning of two X monomers in a +1 zipper interstrand motif. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

U2 - 10.1002/ejoc.200500379

DO - 10.1002/ejoc.200500379

M3 - Journal article

SN - 1434-193X

VL - 2005

SP - 5184

EP - 5188

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 24

ER -

Synthesis and Thermal Denaturation Studies of Conformationally Restricted 3'-C-Ethynyl-3'-O,4'-C-Methyleneribonucleotides

Abstract

Adgang til dokumentet

AUB Link

Fingeraftryk

Citationsformater