Synthesis of molecular imprinted beta cyclodextrins oligomers in water

Donghong Yu, Anne Louise Nielsen, Lone Bach, Henriette Sie Woldum, Guy Bauw, Kristian Raaby Poulsen, Reinhard Wimmer, Kim Lambertsen Larsen

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceabstrakt i proceedingForskning

Resumé

hydrophobic molecules in aqueous solution, however, with limited selectivity. Templated synthesis of Cyclodextrin polymers was introduced by Komiyama. By use of simple templates, such as cholesterol, polymers with improved selectivity for the template molecules were achieved. In most of these studies the synthesis was performed in non-aqueous solvents. Since water plays a major role in the formation and stabilization of inclusion complexes between cyclodextrins and a large number of guest molecules, the formation and stability of inclusion complexes, biosensor applications aim at detecting compounds in aqueous solution and, therefore, molecular imprinting of cyclodextrins polymers in aqueous solution is of great interest. In this paper, molecular imprinting of beta cyclodextrins has been performed in water by use of diiodobenzene as template and epichlorohydrin as a crosslinker. Inclusion complex formation between them prior to polymerization was proven by 2d-ROESY NMR. Water soluble CD dimmers were proven by MALDI-TOF MS to be the dominating products after synthesis.
OriginalsprogEngelsk
TitelFirst World congress on Synthetic Receptors
ForlagPergamon Press
Publikationsdato2003
StatusUdgivet - 2003
BegivenhedFirst World Congress on Synthetic Receptors - Lisabon, Portugal
Varighed: 15 okt. 200317 okt. 2003

Konference

KonferenceFirst World Congress on Synthetic Receptors
LandPortugal
ByLisabon
Periode15/10/200317/10/2003

Fingerprint

beta-Cyclodextrins
Oligomers
Molecules
Water
Epichlorohydrin
Cyclodextrins
Biosensors
Polymers
Stabilization
Cholesterol
Polymerization
Nuclear magnetic resonance
cyclodextrin polymer

Citer dette

Yu, D., Nielsen, A. L., Bach, L., Woldum, H. S., Bauw, G., Poulsen, K. R., ... Larsen, K. L. (2003). Synthesis of molecular imprinted beta cyclodextrins oligomers in water. I First World congress on Synthetic Receptors Pergamon Press.
Yu, Donghong ; Nielsen, Anne Louise ; Bach, Lone ; Woldum, Henriette Sie ; Bauw, Guy ; Poulsen, Kristian Raaby ; Wimmer, Reinhard ; Larsen, Kim Lambertsen. / Synthesis of molecular imprinted beta cyclodextrins oligomers in water. First World congress on Synthetic Receptors. Pergamon Press, 2003.
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title = "Synthesis of molecular imprinted beta cyclodextrins oligomers in water",
abstract = "hydrophobic molecules in aqueous solution, however, with limited selectivity. Templated synthesis of Cyclodextrin polymers was introduced by Komiyama. By use of simple templates, such as cholesterol, polymers with improved selectivity for the template molecules were achieved. In most of these studies the synthesis was performed in non-aqueous solvents. Since water plays a major role in the formation and stabilization of inclusion complexes between cyclodextrins and a large number of guest molecules, the formation and stability of inclusion complexes, biosensor applications aim at detecting compounds in aqueous solution and, therefore, molecular imprinting of cyclodextrins polymers in aqueous solution is of great interest. In this paper, molecular imprinting of beta cyclodextrins has been performed in water by use of diiodobenzene as template and epichlorohydrin as a crosslinker. Inclusion complex formation between them prior to polymerization was proven by 2d-ROESY NMR. Water soluble CD dimmers were proven by MALDI-TOF MS to be the dominating products after synthesis.",
author = "Donghong Yu and Nielsen, {Anne Louise} and Lone Bach and Woldum, {Henriette Sie} and Guy Bauw and Poulsen, {Kristian Raaby} and Reinhard Wimmer and Larsen, {Kim Lambertsen}",
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Yu, D, Nielsen, AL, Bach, L, Woldum, HS, Bauw, G, Poulsen, KR, Wimmer, R & Larsen, KL 2003, Synthesis of molecular imprinted beta cyclodextrins oligomers in water. i First World congress on Synthetic Receptors. Pergamon Press, First World Congress on Synthetic Receptors, Lisabon, Portugal, 15/10/2003.

Synthesis of molecular imprinted beta cyclodextrins oligomers in water. / Yu, Donghong; Nielsen, Anne Louise; Bach, Lone; Woldum, Henriette Sie; Bauw, Guy; Poulsen, Kristian Raaby; Wimmer, Reinhard; Larsen, Kim Lambertsen.

First World congress on Synthetic Receptors. Pergamon Press, 2003.

Publikation: Bidrag til bog/antologi/rapport/konference proceedingKonferenceabstrakt i proceedingForskning

TY - ABST

T1 - Synthesis of molecular imprinted beta cyclodextrins oligomers in water

AU - Yu, Donghong

AU - Nielsen, Anne Louise

AU - Bach, Lone

AU - Woldum, Henriette Sie

AU - Bauw, Guy

AU - Poulsen, Kristian Raaby

AU - Wimmer, Reinhard

AU - Larsen, Kim Lambertsen

PY - 2003

Y1 - 2003

N2 - hydrophobic molecules in aqueous solution, however, with limited selectivity. Templated synthesis of Cyclodextrin polymers was introduced by Komiyama. By use of simple templates, such as cholesterol, polymers with improved selectivity for the template molecules were achieved. In most of these studies the synthesis was performed in non-aqueous solvents. Since water plays a major role in the formation and stabilization of inclusion complexes between cyclodextrins and a large number of guest molecules, the formation and stability of inclusion complexes, biosensor applications aim at detecting compounds in aqueous solution and, therefore, molecular imprinting of cyclodextrins polymers in aqueous solution is of great interest. In this paper, molecular imprinting of beta cyclodextrins has been performed in water by use of diiodobenzene as template and epichlorohydrin as a crosslinker. Inclusion complex formation between them prior to polymerization was proven by 2d-ROESY NMR. Water soluble CD dimmers were proven by MALDI-TOF MS to be the dominating products after synthesis.

AB - hydrophobic molecules in aqueous solution, however, with limited selectivity. Templated synthesis of Cyclodextrin polymers was introduced by Komiyama. By use of simple templates, such as cholesterol, polymers with improved selectivity for the template molecules were achieved. In most of these studies the synthesis was performed in non-aqueous solvents. Since water plays a major role in the formation and stabilization of inclusion complexes between cyclodextrins and a large number of guest molecules, the formation and stability of inclusion complexes, biosensor applications aim at detecting compounds in aqueous solution and, therefore, molecular imprinting of cyclodextrins polymers in aqueous solution is of great interest. In this paper, molecular imprinting of beta cyclodextrins has been performed in water by use of diiodobenzene as template and epichlorohydrin as a crosslinker. Inclusion complex formation between them prior to polymerization was proven by 2d-ROESY NMR. Water soluble CD dimmers were proven by MALDI-TOF MS to be the dominating products after synthesis.

M3 - Conference abstract in proceeding

BT - First World congress on Synthetic Receptors

PB - Pergamon Press

ER -

Yu D, Nielsen AL, Bach L, Woldum HS, Bauw G, Poulsen KR et al. Synthesis of molecular imprinted beta cyclodextrins oligomers in water. I First World congress on Synthetic Receptors. Pergamon Press. 2003