Systemic photoprotection in 2021

T. Searle, F.R. Ali, F. Al-Niaimi*

*Kontaktforfatter

Publikation: Bidrag til tidsskriftReview (oversigtsartikel)peer review

1 Citationer (Scopus)
70 Downloads (Pure)

Abstract

Systemic photoprotection aims to negate the negative effects of ultraviolet radiation-induced DNA damage. Systemic supplements may be used as a monotherapy or in combination with topical sunscreens. Using the keywords ‘carotenoids’, ‘flavonoids’, ‘systemic photoprotection’, ‘polyphenols’ and ‘polypodium leucotomos extract’, we searched the databases MEDLINE and EMBASE to find relevant English-language articles. Few trials have supported the use of any of these supplements as monotherapy, impeding the recommendation of these systemic supplements as an alternative to sunscreen for photoprotection. Nicotinamide has exhibited clinically relevant benefits in reducing nonmelanoma skin cancers in trials and could be recommended as an adjunctive therapy for the most vulnerable indviduals. Further research is required, which needs to be of higher statistical power, using more clinically meaningful outcome measures with comparison to the current gold standard of care (topical photoprotection) to support the use of alternative therapies in clinical practice.

OriginalsprogEngelsk
TidsskriftClinical and Experimental Dermatology
Vol/bind46
Udgave nummer7
Sider (fra-til)1189-1204
Antal sider16
ISSN0307-6938
DOI
StatusUdgivet - okt. 2021

Fingeraftryk

Dyk ned i forskningsemnerne om 'Systemic photoprotection in 2021'. Sammen danner de et unikt fingeraftryk.

Citationsformater