Temporal trends in mortality in patients with rheumatoid arthritis: a Danish population-based matched cohort study

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Abstract

OBJECTIVES: To investigate the 5-year all-cause mortality in patients with rheumatoid arthritis (RA) compared with the general population.

METHODS: Nationwide population-based matched cohort study. RA patients diagnosed between 1996 and the end of 2015 were identified using administrative heath registries and followed until the end of 2020 allowing 5 years of follow-up. Patients with incident RA were matched 1:5 on year of birth and sex with non-RA individuals from the Danish general population. Time-to-event analyses were performed using the pseudo-observation approach.

RESULTS: Compared with matched controls in 1996-2000, the risk difference for RA patients ranged from 3.5% (95%CI 2.7-4.4%) in 1996-2000 to -1.6% (95%CI -2.3 to -1.0%) in 2011-2015, and the relative risk from 1.3 (95%CI 1.2-1.4) in 1996-2000 to 0.9 (95%CI 0.8-0.9) in 2011-2015. The age-adjusted 5-year cumulative incidence proportion of death for a 60-year-old RA patient decreased from 8.1% (95%CI 7.3-8.9%) when diagnosed in 1996-2000 to 2.9% (95%CI 2.3-3.5%) in 2011-2015, and for matched controls from 4.6% (95%CI 4.2-4.9%) to 2.1% (95%CI 1.9-2.4%). Excess mortality persisted in women with RA throughout the study period, while the mortality risk for men with RA in 2011-2015 was similar to their matched controls.

CONCLUSIONS: Enhanced improvement in mortality was found in RA patients compared with matched controls, but for sex-specific differences excess mortality was only persistent in females with RA.

OriginalsprogEngelsk
Artikelnummerkead325
TidsskriftRheumatology
ISSN1462-0324
DOI
StatusE-pub ahead of print - 7 jul. 2023

Bibliografisk note

© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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