Abstract
INTRODUCTION: Marine n-3 polyunsaturated fatty acids (PUFA) have a variety of anti-inflammatory properties. This study evaluated the effect of n-3 PUFA in a low, but recommended cardioprotective dosage on the formation of 5-lipoxygenase pathway metabolites in overweight subjects. MATERIALS AND METHODS: Fifty subjects were randomized to 1.1g of n-3 PUFA or olive oil for 6 weeks. RESULTS: Leukotriene B(4) formation decreased by 14% in the n-3 PUFA group which proved to be significant within the group (p=0.005) but not between groups (p=0.25). The formation of 5-hydroxyeicosatetraenoic acid (5-HETE) did not differ significantly between the groups. In the n-3 PUFA group, both 5-hydroxyeicosapentaenoic (5-HEPE) acid and leukotriene B(5) increased significantly compared to the control group (p
Originalsprog | Engelsk |
---|---|
Tidsskrift | Prostaglandins, Leukotrienes & Essential Fatty Acids |
Vol/bind | 87 |
Sider (fra-til) | 43-8 |
Antal sider | 6 |
ISSN | 0952-3278 |
DOI | |
Status | Udgivet - 2012 |
Udgivet eksternt | Ja |