The Effect of Schizophrenia on Major Adverse Cardiac Events, Length of Hospital Stay and Prevalence of Somatic Comorbidities Following Acute Coronary Syndrome

Rubina Attar, Jan Brink Valentin, Phillip Freeman, Pontus Andell, Jørgen Aagaard, Svend Eggert Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

14 Citationer (Scopus)

Abstrakt

Aims We aimed to investigate major adverse cardiac events (MACE: defined as all-cause mortality, re-infarction, and stroke), length of hospital stays (LOS), and comorbidities following acute coronary syndrome (ACS) in a population with schizophrenia. Methods and results This Danish register study included patients diagnosed with ACS in the period between 1995 and 2013 with a preceding diagnosis of schizophrenia (n = 726). Each patient was matched to a psychiatric healthy control 1:2 on sex, age, year of ACS diagnosis, and number of comorbidities (total n = 2178). After performing Cox regression and Kaplan-Meier analyses, we found that patients with schizophrenia had an increased risk of MACE [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.45-1.81], all-cause mortality (HR 2.54, 95% CI 2.22-2.90), and stroke (HR 1.51, 95% CI 1.15-1.99). No differences were found in the re-infarction rates and LOS between the populations. Patients with schizophrenia had higher prevalence's diabetes, anaemia, heart failure, cardiomyopathy, chronic obstructive lung disease, and stroke. Nonetheless, we found lower prevalence's of hypertension and hyperlipidaemia. Conclusion Schizophrenia is associated with an increased risk of MACE despite a lower prevalence of some diagnosed traditional cardiac risk factors which may indicate underdiagnosing of these. Awareness of treatment bias may improve this increased risk.

OriginalsprogEngelsk
TidsskriftEuropean heart journal. Quality of care & clinical outcomes
Vol/bind5
Udgave nummer2
Sider (fra-til)121–126
Antal sider6
ISSN2058-1742
DOI
StatusUdgivet - apr. 2019

Fingeraftryk

Dyk ned i forskningsemnerne om 'The Effect of Schizophrenia on Major Adverse Cardiac Events, Length of Hospital Stay and Prevalence of Somatic Comorbidities Following Acute Coronary Syndrome'. Sammen danner de et unikt fingeraftryk.

Citationsformater