TY - JOUR
T1 - The impact of avoiding cardiopulmonary by-pass during coronary artery bypass surgery in elderly patients: the Danish On-pump Off-pump Randomisation Study (DOORS)
AU - Houlind, Kim
AU - Kjeldsen, Bo Juul
AU - Madsen, Susanne Nørgaard
AU - Rasmussen, Bodil Steen
AU - Holme, Susanne Juel
AU - Schmidt, Thomas Andersen
AU - Haahr, Poul Erik
AU - Mortensen, Poul Erik
AU - Doors Study Group
AU - Houlind, Kim
AU - Kjeldsen, Bo Juul
AU - Madsen, Susanne Nørgaard
AU - Rasmussen, Bodil Steen
AU - Holme, Susanne
AU - Mortensen, Poul Erik
AU - Hjortdal, Vibeke
AU - Lerbjerg, Gert
AU - Niebuhr, Uffe
AU - Aggestrup, Soren
AU - Nielsen, Per Hostrup
AU - Sollid, Jorn
AU - Videbæk, Jørgen
AU - Sergeant, Paul
AU - Stahle, Elisabeth
AU - Wouters, Patrick
AU - Paulsen, Peter Kildeberg
AU - Hassager, Christian
AU - Klausen, Ib Chr.
AU - Andersen, Grethe
AU - Meden, Per
AU - Modrau, Boris
AU - Sørensen, Henrik Toft
AU - Johnsen, Søren Paaske
AU - Andersen, Niels Trolle
AU - Jakobsen, Jakob
AU - Andreasen, Jan Jesper
AU - Haahr, Poul Erik
AU - Christensen, John
AU - Grønlund, Jens
AU - Jepsen, Mogens Harrits
AU - Pallesen, Peter Appel
AU - Ravkilde, Jan
AU - Aarøe, Jens
AU - Hansen, Peter Riis
AU - Hansen, Henrik Steen
AU - Dalsgaard, Dorthe
AU - Munkholm, Henrik
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass (CPB) and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced. METHODS/DESIGN: The trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres. TRIAL REGISTRATION: ClinicalTrials.gov NCT00123981.
AB - BACKGROUND: Coronary Artery Bypass Graft operation for ischemic heart disease provides improved quality of life and, in some patients, prolonged survival. Concern has, however, been raised about complications that may be related to the use of cardiopulmonary by-pass (CPB) and aortic cross-clamping. It has been hypothesized that when coronary artery by-pass grafting is performed without the use of CPB, the rate of serious complications is reduced. METHODS/DESIGN: The trial is designed as an open, randomized, controlled, clinical trial with blinded assessment of end-points. Patients at or above 70 years of age, referred for surgical myocardial revascularisation, are included and randomised to receive coronary artery by-pass grafting either with or without the use of CPB and aortic cross-clamping. Follow-up is performed by clinical, biochemical, electrocardiographic, and angiographic data that are evaluated by independent committees that are blinded with respect to the result of the randomisation. End points include mortality, stroke, myocardial infarction, graft patency, quality of life, and cost-effectiveness. The trial is performed in four different Danish, cardiac surgery centres. TRIAL REGISTRATION: ClinicalTrials.gov NCT00123981.
U2 - 10.1186/1745-6215-10-47
DO - 10.1186/1745-6215-10-47
M3 - Journal article
SN - 1745-6215
VL - 10
JO - Trials
JF - Trials
ER -