The impact of naloxegol on anal sphincter function - Using a human experimental model of opioid-induced bowel dysfunction

Debbie Grønlund, Jakob L Poulsen, Klaus Krogh, Christina Brock, Donghua Liao, Hans Gregersen, Asbjørn M Drewes, Anne E Olesen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

3 Citationer (Scopus)
OriginalsprogEngelsk
TidsskriftEuropean Journal of Pharmaceutical Sciences
Vol/bind117
Sider (fra-til)187-192
Antal sider6
ISSN0928-0987
DOI
StatusUdgivet - 30 maj 2018

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Anal Canal
Opioid Analgesics
Theoretical Models
Oxycodone
Reflex
Defecation
Symptom Assessment
Constipation
Placebos
Laxatives
Narcotic Antagonists
Manometry
Cross-Over Studies
naloxegol
Therapeutics
Pressure

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title = "The impact of naloxegol on anal sphincter function - Using a human experimental model of opioid-induced bowel dysfunction",
keywords = "Anal sphincter, Constipation, Functional lumen imaging probe, Naloxegol, Opioid-induced bowel dysfunction, Opioids, Recto-anal inhibitory reflex, Defecation/drug effects, Humans, Middle Aged, Male, Young Adult, Time Factors, Adult, Polyethylene Glycols/administration & dosage, Analgesics, Opioid/administration & dosage, Anal Canal/drug effects, Double-Blind Method, Administration, Oral, Treatment Outcome, Pressure, Cross-Over Studies, Constipation/chemically induced, Oxycodone/administration & dosage, Narcotic Antagonists/administration & dosage, Denmark, Morphinans/administration & dosage",
author = "Debbie Gr{\o}nlund and Poulsen, {Jakob L} and Klaus Krogh and Christina Brock and Donghua Liao and Hans Gregersen and Drewes, {Asbj{\o}rn M} and Olesen, {Anne E}",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = "5",
day = "30",
doi = "10.1016/j.ejps.2018.02.008",
language = "English",
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The impact of naloxegol on anal sphincter function - Using a human experimental model of opioid-induced bowel dysfunction. / Grønlund, Debbie; Poulsen, Jakob L; Krogh, Klaus; Brock, Christina; Liao, Donghua; Gregersen, Hans; Drewes, Asbjørn M; Olesen, Anne E.

I: European Journal of Pharmaceutical Sciences, Bind 117, 30.05.2018, s. 187-192.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - The impact of naloxegol on anal sphincter function - Using a human experimental model of opioid-induced bowel dysfunction

AU - Grønlund, Debbie

AU - Poulsen, Jakob L

AU - Krogh, Klaus

AU - Brock, Christina

AU - Liao, Donghua

AU - Gregersen, Hans

AU - Drewes, Asbjørn M

AU - Olesen, Anne E

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/5/30

Y1 - 2018/5/30

KW - Anal sphincter

KW - Constipation

KW - Functional lumen imaging probe

KW - Naloxegol

KW - Opioid-induced bowel dysfunction

KW - Opioids

KW - Recto-anal inhibitory reflex

KW - Defecation/drug effects

KW - Humans

KW - Middle Aged

KW - Male

KW - Young Adult

KW - Time Factors

KW - Adult

KW - Polyethylene Glycols/administration & dosage

KW - Analgesics, Opioid/administration & dosage

KW - Anal Canal/drug effects

KW - Double-Blind Method

KW - Administration, Oral

KW - Treatment Outcome

KW - Pressure

KW - Cross-Over Studies

KW - Constipation/chemically induced

KW - Oxycodone/administration & dosage

KW - Narcotic Antagonists/administration & dosage

KW - Denmark

KW - Morphinans/administration & dosage

UR - http://www.scopus.com/inward/record.url?scp=85042504710&partnerID=8YFLogxK

U2 - 10.1016/j.ejps.2018.02.008

DO - 10.1016/j.ejps.2018.02.008

M3 - Journal article

VL - 117

SP - 187

EP - 192

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

ER -