The Impact of Opioid Treatment on Regional Gastrointestinal Transit

Jakob Lykke Poulsen, Matias Nilsson, Christina Brock, Thomas Holm Sandberg, Klaus Krogh, Asbjørn Mohr Drewes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

45 Citationer (Scopus)

Abstract

Background/Aims: To employ an experimental model of opioid-induced bowel dysfunction (OIBD) in healthy human volunteers, and evaluate the impact of opioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility assessed by questionnaires and regional GI transit times using the 3 dimension (3D)-Transit system.

Methods: Twenty-five healthy males were randomly assigned to oxycodone or placebo for five days in a double blind, cross-over design. Adverse GI effects were measured with the bowel function index (BFI), gastrointestinal symptom rating scale (GSRS), patient assessment of constipation symptom questionnaire (PAC-SYM), and Bristol stool form scale. Regional GI transit times were determined using the 3D-Transit system and segmental transit times in the colon were determined using a custom Matlab graphical user interface.

Results: GI symptom scores increased significantly across all applied GI questionnaires during opioid treatment. Oxycodone increased median total GI transit time from 22.2 to 43.9 hours (P< 0.001), segmental transit times in the cecum and ascending colon from 5.7 to 9.9 hours (P= 0.010), rectosigmoid colon transit from 2.7 to 9.0 hours (P= 0.040), and colorectal transit time from 18.6 to 38.6 hours (P= 0.001). No association between questionnaire scores and segmental transit times were detected.

Conclusions: Self-assessed GI adverse effects and increased GI transit times in different segments were induced during oxycodone treatment. This detailed information about segmental changes in motility has great potential for future interventional head-to-head trials of different laxative regimes for prevention and treatment of constipation.

OriginalsprogEngelsk
TidsskriftNeurogastroenterology and Motility
Vol/bind22
Udgave nummer2
Sider (fra-til)282-291
Antal sider10
ISSN1365-2982
DOI
StatusUdgivet - 2016

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