TY - JOUR
T1 - The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia
AU - Papaioannou, Dimitrios
AU - Petri, Andreas
AU - Dovey, Oliver M
AU - Terreri, Sara
AU - Wang, Eric
AU - Collins, Frances A
AU - Woodward, Lauren A
AU - Walker, Allison E
AU - Nicolet, Deedra
AU - Pepe, Felice
AU - Kumchala, Prasanthi
AU - Bill, Marius
AU - Walker, Christopher J
AU - Karunasiri, Malith
AU - Mrózek, Krzysztof
AU - Gardner, Miranda L
AU - Camilotto, Virginia
AU - Zitzer, Nina
AU - Cooper, Jonathan L
AU - Cai, Xiongwei
AU - Rong-Mullins, Xiaoqing
AU - Kohlschmidt, Jessica
AU - Archer, Kellie J
AU - Freitas, Michael A
AU - Zheng, Yi
AU - Lee, Robert J
AU - Aifantis, Iannis
AU - Vassiliou, George
AU - Singh, Guramrit
AU - Kauppinen, Sakari
AU - Bloomfield, Clara D
AU - Dorrance, Adrienne M
AU - Garzon, Ramiro
N1 - Publisher Correction:
"The original version of this Article contained an error in the author affiliations.
Affiliation number 9 incorrectly read “Department of Molecular Medicine, University of Pavia, Pavia, USA”
This has now been corrected in both the PDF and HTML versions of the Article."
(Nat Commun 11:204 (2020). https://doi.org/10.1038/s41467-019-13969-7).
Author Correction:
"The original version of this article omitted the following from the Acknowledgements: R.G. was supported by a Scholar in Clinical Research award from The Leukemia & Lymphoma Society."
This has now been corrected in both the PDF and HTML versions of the article.
(Nat Commun 11:3878 (2020). https://doi.org/10.1038/s41467-020-17746-9.
PY - 2019/11/25
Y1 - 2019/11/25
N2 - Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
AB - Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts.
UR - http://www.scopus.com/inward/record.url?scp=85075548044&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13259-2
DO - 10.1038/s41467-019-13259-2
M3 - Journal article
C2 - 31767858
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5351
ER -