TY - JOUR
T1 - The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes
AU - Drago, Antonio
AU - Crisafulli, Concetta
AU - Sidoti, Antonina
AU - Serretti, Alessandro
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.
AB - The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.
KW - Animals
KW - Brain/anatomy & histology
KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
KW - Cyclic AMP-Dependent Protein Kinases/metabolism
KW - Depressive Disorder/genetics
KW - Dopamine/metabolism
KW - Excitatory Amino Acid Agents
KW - Glutamic Acid/metabolism
KW - Humans
KW - Mitogen-Activated Protein Kinases/metabolism
KW - Neural Pathways/anatomy & histology
KW - Nitric Oxide/metabolism
KW - Norepinephrine/metabolism
KW - Phenotype
KW - Protein Kinase C/metabolism
KW - Receptors, Dopamine/metabolism
KW - Serotonin/metabolism
KW - Signal Transduction/physiology
U2 - 10.1016/j.pneurobio.2011.05.009
DO - 10.1016/j.pneurobio.2011.05.009
M3 - Review article
C2 - 21723912
SN - 0301-0082
VL - 94
SP - 418
EP - 460
JO - Progress in Neurobiology
JF - Progress in Neurobiology
IS - 4
ER -